Recovery, Fatigability, and Proteomic Response to Aerobic Exercise Training in Healthy Individuals
Completed · Not applicable
Conditions studied: Adult, Fatigue
In brief
The purpose of this protocol is to investigate the role of expired non-metabolic carbon dioxide in the relationship between fatigability and recovery and the response to aerobic exercise training in healthy individuals. Both fatigability and recovery are profoundly influenced by mitochondrial energetics which can be inhibited by ionic by-product accumulation during exercise. Buffering mechanisms of these fatigue-inducing ions releases non-metabolic carbon dioxide (CO2) that can be measured as expired CO2 (VCO2) during cardiopulmonary exercise testing (CPET), however the role of non-metabolic VCO2 in the relationship between fatigability and recovery has yet to be investigated. Furthermore, this study aims to identify the how the patterns of proteins in healthy individuals respond to aerobic exercise training (e.g. stationary cycling) over approximately one month. The underlying mechanisms of recovery after physical activity, including mechanisms or biological pathways that could be highlighted by analysis of proteins in urine, could add to scientific knowledge regarding physical activity tolerance and potential exercise interventions. This knowledge could eventually assist with designing precise and personalized exercise interventions to improve physical activity performance. The investigators hypothesize that 1) non-metabolic CO2 will be at least moderately associated with the inverse relationship between fatigability and recovery; and 2) highly active adults, compared to sedentary individuals, will exhibit differential proteomic patterns in response to an initial acute bout and subsequent repeated bouts of aerobic exercise.
Key facts
- Study ID
- NCT03800342
- Run by
- George Mason University
- People needed
- 21
- Starts
- 2019-01-22
- Expected to finish
- 2019-04-24
- Last updated by the study team
- 2019-05-16
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- age 18-60
- body mass index > 19 to <35 kg/m2
- able to pedal leg cycle ergometer
- able to comprehend and speak English
You may not qualify if…
- diabetes mellitus
- significant pulmonary dysfunction (eg. chronic obstructive lung disease; interstitial lung disease)
- hypertension
- anemia
- stroke
- cancer (other than melanoma)
- cardiac, pulmonary, thyroid, autoimmune, musculoskeletal, neurological, metabolic bone, mitochondrial, hepatic, renal, and/or psychiatric disease
- abnormal blood lipids
- active substance abuse or cognitive impairment
- chronic infection requiring antiviral or antibiotic treatment
- taking any medications that may limit exercise capacity or the ability to adapt to aerobic exercise training
- previously or currently on anticoagulant therapy or therapeutic hormone replacement/supplementation (excluding birth control)
- pregnant
- smoking
Where it is running
- George Mason University — Fairfax, Virginia, United States
Full record on ClinicalTrials.gov
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