Study on Impact of Maximal Strength Training in Patients With COPD

Recruiting now · Not applicable

Conditions studied: Chronic Obstructive Pulmonary Disease

In brief

In the context of pulmonary rehabilitation of COPD patients, recent guidelines and metanalysis describe that Resistance Training (RT) can be successfully performed alone or in conjunction with Endurance Training (ET) without evidence of adverse events. Maximal Strength Training (MST) is a kind of RT typically performed at \~85-90% of 1RM with maximal velocity to be developed in the concentric phase. Recent literature indicates a significant amelioration on the Rate of Force Development (RFD) after MST in healthy subjects, post-menopausal woman and older populations. When comparing to the conventional ET, MST generates a little change in muscle mass (no hypertrophy), but a much greater improvement in the RFD. It has been described that neural adjustments play a major role in the MST-induced adaptations. MST is also well documented to improve aerobic endurance by improving walking work efficiency. Only a small cohort study of COPD patients was conducted, describing that MST can meaningfully improve strength and RFD, with an increase of around 32% for mechanical efficiency and a decrease of the perceived effort during submaximal job. This improvement could determine best performances in daily activities and a best quality of life. The main aims of this physiological pilot randomized controlled trail will be to evaluate feasibility and efficacy of the MST compared to standard ET on strength, effort tolerance, fatigue, economy of walking, dyspnea and risk of falls in a populations of COPD patients, in a short and middle term (6 months).

Key facts

Study ID

NCT03799354

Run by

Istituti Clinici Scientifici Maugeri SpA

People needed

20

Starts

2019-09-18

Expected to finish

2026-07-31

Last updated by the study team

2026-02-23

Who can join

Age: 50 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• COPD clinical definition according to GOLD guidelines with forced expiratory volume (FEV1)/ forced vital capacity (FVC) < 70%, and FEV1 < 50% of predicted
• stable clinical condition

You may not qualify if…

• pulmonary diseases other than COPD
• type II diabetes or other metabolic diseases
• malign disease
• a respiratory tract infection within the last 4 wks
• long oxygen therapy use.

Where it is running

• ICS Maugeri IRCCS, Respiratory Rehabilitation of the Institute of Lumezzane — Lumezzane, Brescia, Italy (enrolling)

Full record on ClinicalTrials.gov

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