Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) in Previously Treated Participants With Select Solid Tumors (MK-7902-005/E7080-G000-224/LEAP-005)

Completed · Phase 2

Conditions studied: Advanced Solid Tumors, Triple Negative Breast Cancer, Ovarian Cancer, Gastric Cancer, Colorectal Cancer, Glioblastoma, Biliary Tract Cancers, Pancreatic Cancer

In brief

The purpose of this study is to determine the safety and efficacy of combination therapy with pembrolizumab (MK-3475) and lenvatinib (E7080/MK-7902) in participants with triple negative breast cancer (TNBC), ovarian cancer, gastric cancer, colorectal cancer (CRC), glioblastoma (GBM), biliary tract cancers (BTC), or pancreatic cancer.

Key facts

Study ID: NCT03797326
Run by: Merck Sharp & Dohme LLC
People needed: 611
Starts: 2019-02-12
Expected to finish: 2024-10-28
Last updated by the study team: 2026-05-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Has a histologically or cytologically-documented, advanced (metastatic and/or unresectable) solid tumor that is incurable and for which prior standard systemic therapy has failed in one of the following cohorts: TNBC, Ovarian Cancer, Gastric Cancer, Colorectal Cancer, GBM, BTC (intrahepatic, extrahepatic cholangiocarcinoma and gall bladder cancer; excludes Ampulla of Vater), Pancreatic Cancer
Must have progressed on or since the last treatment
Has measurable disease per RECIST 1.1 (RANO for the GBM cohort) as assessed by the local site investigator/radiology and confirmed by BICR
Has provided a PD-L1 evaluable archival tumor tissue sample or newly obtained core or excisional biopsy of a tumor lesion not previously irradiated
Male participants agree to use approved contraception during the treatment period for at least 7 days after the last dose of lenvatinib, or refrain from heterosexual intercourse during this period
Female participants are not pregnant or breastfeeding, and are not a woman of childbearing potential (WOCBP), OR are a WOCBP that agrees to use contraception during the treatment period (or 14 days prior to the initiation of study treatment for oral contraception) and for at least 120 days post pembrolizumab, or 30 days post lenvatinib, whichever occurs last
Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1 within 3 days of study treatment initiation
Has adequate organ function
For Triple Negative Breast Cancer Participants:
Has received one or 2 prior lines of therapy
Has Lactate Dehydrogenase (LDH) <2.0 x Upper Limit of Normal (ULN)
Has locally determined results for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 tumor analyses
For Ovarian Cancer Participants:
Has primary ovarian cancer and has received 3 prior lines of therapy.
For Gastric Cancer Participants:
Has received 2 prior lines of therapy. Note: Gastric cancer will include participants with both gastric and gastroesophageal junction (GEJ) adenocarcinoma. Participants with squamous cell carcinoma histology are not eligible
For Colorectal Cancer Participants:
Has received 2 prior lines of therapy
For GBM Participants:
Has failed initial systemic therapy for newly diagnosed GBM
Have the following time periods elapsed before the projected start of scheduled study treatment: 1) at least 3 weeks from prior surgical resection, 2) at least 1 week from stereotactic biopsy, 3) at least 6 months from completion of prior radiotherapy, 4) at least 4 weeks (or 5 half-lives, whichever is shorter) from any investigational agent, 5) at least 4 weeks from cytotoxic therapy, 6) at least 6 weeks from antibodies, 7) at least 4 weeks (or 5 half-lives, whichever is shorter) from other antitumor therapies and 1 week for cancer vaccines
Be neurologically stable (e.g. without a progression of neurologic symptoms or requiring escalating doses of systemic steroid therapy within last 2 weeks) and clinically stable
Has histologically confirmed World Health Organization (WHO) Grade IV GBM
Has locally determined result for O\^6-methylguanine-DNA methyltransferase (MGMT) analysis
For Biliary Tract Cancer Participants:

You may not qualify if…

Has gastrointestinal malabsorption or any other condition that might affect the absorption of lenvatinib
Has present or progressive accumulation of pleural, ascitic, or pericardial fluid requiring drainage or diuretic drugs within 2 weeks prior to enrollment (applies to all cohorts except the ovarian cancer cohort)
Has radiographic evidence of encasement or invasion of a major blood vessel or of intratumoral cavitation. Participants with portal vein invasion (Vp4), inferior vena cava, or cardiac involvement based on imaging in the BTC cohort are not eligible for enrollment
Has clinical significant hemoptysis or tumor bleeding within 2 weeks prior to the first dose of study treatment
Has significant cardiovascular impairment within 12 months of the first dose of study treatment, such as history of congestive heart failure greater than New York Heart Association (NYHA) Class II, unstable angina, myocardial infarction or cerebrovascular accident (CVA), or cardiac arrhythmia associated with hemodynamic instability
Has a history of arterial thromboembolism within 12 months of start of study treatment
Has a known additional malignancy that is progressing or has required active treatment within the past 3 years.
Has a serious nonhealing wound, ulcer or bone fracture
Has had major surgery within 3 weeks prior to first dose of study interventions
Has biologic response modifiers therapy (e.g. granulocyte colony-stimulating factor) within 4 weeks before study entry
Has preexisting ≥Grade 3 gastrointestinal (GI) or non-gastrointestinal fistula
Has received prior therapy with lenvatinib, an anti-PD-1, anti-PD-L1, or anti PD-L2 agent or with an agent directed to another stimulatory or co-inhibitory T-cell receptor (e.g. cytotoxic T-lymphocyte-associated protein 4 [CTLA-4], Tumor necrosis factor receptor superfamily, member 4 [OX 40], tumor necrosis factor receptor superfamily member 9 [CD137])
Has received prior systemic anti-cancer therapy including investigational agents within 4 weeks prior to study treatment start
If participant received major surgery, they must have recovered adequately from the toxicity and/or complications from the intervention prior to starting study treatment
Has received prior radiotherapy within 2 weeks of start of study treatment. Participants must have recovered from all radiation-related toxicities, not require corticosteroids, and not have had radiation pneumonitis. A 1-week washout is permitted for palliative radiation (≤2 weeks of radiotherapy) to non-central nervous system (CNS) disease
Has received a live vaccine within 30 days prior to the first dose of study treatment
Has known intolerance to lenvatinib (and/or any of the excipients)
Is currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of study treatment
Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior the first dose of study treatment
Has known active CNS metastases and/or carcinomatous meningitis
Has tumors involving the brain stem
Has severe hypersensitivity (≥Grade 3) to pembrolizumab and/or any of its excipients
Has an active autoimmune disease that has required systemic treatment in past 2 years
Has a history of (non-infectious) pneumonitis that required steroids or has current pneumonitis
Has an active infection requiring systemic therapy

Where it is running

Cedars Sinai Medical Center ( Site 0003) — Los Angeles, California, United States
University of California Davis Comprehensive Cancer Center ( Site 0005) — Sacramento, California, United States
University of Colorado, Anschutz Cancer Pavilion ( Site 0007) — Aurora, Colorado, United States
University of Florida-Health Cancer Center-Orlando ( Site 0015) — Orlando, Florida, United States
Rutgers Cancer Institute of New Jersey ( Site 0009) — New Brunswick, New Jersey, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 0023) — New York, New York, United States
Sanford Fargo Medical Center ( Site 0059) — Fargo, North Dakota, United States
Lehigh Valley Hospital- Cedar Crest ( Site 0047) — Allentown, Pennsylvania, United States
Sanford Cancer Center ( Site 0058) — Sioux Falls, South Dakota, United States
West Cancer Center - East Campus ( Site 0018) — Germantown, Tennessee, United States
Mary Crowley Cancer Research Centers - Medical City Hospital ( Site 0049) — Dallas, Texas, United States
Swedish Medical Center ( Site 0021) — Seattle, Washington, United States
University of Wisconsin Carbone Cancer Center ( Site 0017) — Madison, Wisconsin, United States
Fundacion Favaloro para la Docencia e Investigacion Medica ( Site 2106) — Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Hospital Aleman ( Site 2100) — Buenos Aires, Buenos Aires F.D., Argentina
Hospital Britanico de Buenos Aires ( Site 2109) — Ciudad de Buenos Aires, Buenos Aires F.D., Argentina
Instituto de Oncologia de Rosario ( Site 2105) — Rosario, Santa Fe Province, Argentina
CEMIC ( Site 2104) — Buenos Aires, Argentina
IDIM Instituto de Diagnostico e Investigaciones Metabolicas ( Site 2101) — Caba, Argentina
Royal Brisbane and Women s Hospital ( Site 0901) — Herston, Queensland, Australia
Alfred Health ( Site 0902) — Melbourne, Victoria, Australia
Sir Charles Gairdner Hospital ( Site 0903) — Nedlands, Western Australia, Australia
BC Cancer - Abbotsford ( Site 0200) — Abbotsford British Columbia, British Columbia, Canada
CancerCare Manitoba ( Site 0201) — Winnipeg, Manitoba, Canada
City of Hope ( Site 0002) — Duarte, California, United States

Full record on ClinicalTrials.gov

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