Pilot-Tart Cherry, Mitral Transcriptome, and POAF Incidence

Running, not enrolling · Phase 1/Phase 2

Conditions studied: Post-operative Atrial Fibrillation (POAF)

In brief

Assess impact of Tart Cherry Concentrate in cardiac surgical patients on POAF and related clinical and economic outcomes. Measure inflammation gene transcripts in cardiac tissue.

Key facts

Study ID

NCT03793465

Run by

University of Michigan

People needed

50

Starts

2019-02-08

Expected to finish

2027-01-01

Last updated by the study team

2026-02-05

Who can join

Age: 50 and older, up to 79. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males and female patients (age 50-79) at the Mitral Valve Clinic/CVC undergoing elective cardiac surgery for mitral valve repair without the Cox MAZE procedure (MVR patients also undergoing CABG and/or tricuspid valve repair are also eligible)
• In sinus rhythm (no pre-operative atrial fibrillation, no hx of AF)

You may not qualify if…

• Age ≥ 80 years
• Diagnosed pre-operative chronic or paroxysmal AF
• Prior ablation procedure for AF
• Previous cardiac surgery
• Implanted pacemaker
• Active smoker
• Comorbidities such as congenital or cardiac re-operation
• Use of antiarrhythmic agents
• Active inflammatory or infectious disease or malignancy
• Diagnosed autoimmune disease
• Corticosteroid or other immunomodulatory or immunosuppressive medication
• Known sensitivity to sorbitol
• Known gastric sensitivity to acidic juices like orange juice

Where it is running

• University of Michigan — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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