Genetic and Epigenetic Basis of Chronic Wounds

Recruiting now

Conditions studied: Chronic Wounds

In brief

This pilot study is designed for chronic wounds that fail to heal in a timely manner carry specific genetic signatures. These genetic signatures will be studied using debrided wound tissue that is removed by the wound care provider as part of standard of care. The reference genomic signature will be evaluated by obtaining blood samples and will be compared with wound debrided tissue genomic signature to understand wound specific genomic changes.

Key facts

Study ID

NCT03793062

Run by

University of Pittsburgh

People needed

256

Starts

2018-12-04

Expected to finish

2028-12-31

Last updated by the study team

2026-04-14

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Willing to comply with protocol instructions, including all study visits and study activities.
• Chronic wounds (> than four weeks since onset)
• Clinically diagnosed diabetic or non-diabetic ulcer.
• For patients with multiple wounds, the largest wound will be used for the study.

You may not qualify if…

• Individuals who are deemed unable to understand the procedures, risks and benefits of the study,(i.e. unable to provide informed consent)
• Pregnant females (self-declared) or lactating
• Subjects with marked immunodeficiency (HIV/AIDS or immune-suppressive medications)
• Prisoners

Where it is running

• UPMC Wound Care Centers — Pittsburgh, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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