Nirogacestat for Adults With Desmoid Tumor/Aggressive Fibromatosis (DT/AF)
Completed · Phase 3 · Has a placebo group
Conditions studied: Desmoid Tumor, Aggressive Fibromatosis
In brief
This study evaluates nirogacestat (PF-03084014) in the treatment of desmoid tumor/aggressive fibromatosis (DT/AF). In the double-blind phase, half of the participants will receive nirogacestat while the other half will receive placebo. Once participants are eligible to roll into the open-label phase, they will receive nirogacestat.
Key facts
- Study ID
- NCT03785964
- Run by
- SpringWorks Therapeutics, Inc.
- People needed
- 142
- Starts
- 2019-04-17
- Expected to finish
- 2024-10-17
- Last updated by the study team
- 2025-01-31
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
- DUMC/Duke Cancer Center — Durham, North Carolina, United States
- Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
- James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer Center — Columbus, Ohio, United States
- Oregon Health & Science University-Center for Health & Healing — Portland, Oregon, United States
- Abramson Cancer Center at Pennsylvania Hospital — Philadelphia, Pennsylvania, United States
- Fox Chase Cancer Center — Philadelphia, Pennsylvania, United States
- UPMC Hillman Cancer Center — Pittsburgh, Pennsylvania, United States
- Henry-Joyce Cancer Clinic — Nashville, Tennessee, United States
- UT Southwestern Medical Center — Dallas, Texas, United States
- The University of Texas MD Anderson Cancer Center — Houston, Texas, United States
- Seattle Cancer Care Alliance — Seattle, Washington, United States
- University of Wisconsin Clinical Science Center — Madison, Wisconsin, United States
- Froedtert Hospital & the Medical College of Wisconsin — Milwaukee, Wisconsin, United States
- Institut Jules Bordet-Medical Oncology — Brussels, Belgium
- Cliniques Universitaires Saint-Luc, Institut Roi Albert II — Brussels, Belgium
- UZ Gent — Ghent, Belgium
- UZ Leuven — Leuven, Belgium
- Princess Margaret Cancer Centre — Toronto, Ontario, Canada
- McGill University Health Centre — Montreal, Quebec, Canada
- Helios Klinikum Berlin-Buch — Berlin, Germany
- Universitaetsklinikum Hamburg-Eppendorf — Hamburg, Germany
- Universitätsmedizin Mannheim — Mannheim, Germany
- IRCCS Istituto Ortopedico Rizzoli — Bologna, Italy
- Columbia University Medical Center — New York, New York, United States
Full record on ClinicalTrials.gov
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