Brain, Appetite, Teens, and Exercise

Completed · Not applicable

Conditions studied: Energy Balance, Appetitive Behavior, Obesity

In brief

The long-term goal is to develop effective, evidence-based lifestyle interventions to prevent and treat childhood obesity and related co-morbidities. The short-term goal, and the purpose of this application, is to quantify appetite and neural mechanisms of food reward in overweight/obese (OW/OB) sedentary youth and to quantify changes following the implementation of a physical activity intervention. The central hypothesis is that appetite becomes dysregulated at low levels of physical activity via neural reward pathways, and appetite control will improve following a long-term exercise intervention. The investigators consider this project a pilot study designed to generate data to be used for future external funding opportunities, demonstrate collaboration between researchers, and test the feasibility of the protocols.

Key facts

Study ID

NCT03783390

Run by

Children's Mercy Hospital Kansas City

People needed

19

Starts

2018-09-01

Expected to finish

2019-08-10

Last updated by the study team

2020-05-14

Who can join

Age: 14 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Overweight/obese (BMI ≥85th to <99th percentile for age and sex)
• Weight stable
• Ages 14-17
• No meds that may alter metabolism
• Sedentary (<20 min/day exercise)
• At risk for T2D, according to American Diabetes Association (ADA) criteria:
• family history of T2D in first- or second- degree relative
• Race/ethnicity (Native American, African American, Latino, Asian American, Pacific Islander)
• Signs of insulin resistance
• Maternal history of diabetes for gestational diabetes during child's gestation
• Willing to participate in an exercise program
• Willing to provide permission/assent

You may not qualify if…

• BMI <85th percentile for age and sex
• Weight not stable
• Age <14 or >17
• On meds that may alter metabolism
• Active (>20 min/day exercise)
• Not at risk for T2D, according to American Diabetes Association (ADA) criteria (see above)
• Not willing to participate in an exercise program
• Not willing to provide permission/assent

Where it is running

• Children's Mercy Kansas City — Kansas City, Missouri, United States

Full record on ClinicalTrials.gov

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