A Trial of Vitamin B12 in Septic Shock

Completed · Phase 2 · Has a placebo group

Conditions studied: Septic Shock

In brief

This study will randomize 20 septic shock patients to receive either a single 5 gram dose of IV vitamin B12 (Cyanokit® Meridian Medical Technologies, Columbia, MD) versus placebo in addition to standard of care to test the feasibility of completing clinical and laboratory protocols.

Key facts

Study ID

NCT03783091

Run by

Medical College of Wisconsin

People needed

20

Starts

2019-08-05

Expected to finish

2023-02-23

Last updated by the study team

2026-05-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients at least 18 years of age
• Admitted to the Medical Intensive Care Unit (MICU) service at Froedtert Hospital
• Diagnosis of septic shock, as defined by sepsis-3 criteria

You may not qualify if…

• History of calcium oxaluria

Where it is running

• Medical College of Wisconsin — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

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