Stimulant vs. Non-stimulant Treatments and Reward Processing in Drug-naive Youth at SUD Risk

Recruiting now · Phase 4

Conditions studied: ADHD, Attention Deficit Hyperactivity Disorder

In brief

The study team will examine the effects of FDA approved stimulant and non-stimulant medications for ADHD, among youth with ADHD and with and without Oppositional Defiant Disorder (ODD) or Conduct Disorder (CD), on reward systems of the brain using fMRI.

Key facts

Study ID

NCT03781765

Run by

Icahn School of Medicine at Mount Sinai

People needed

44

Starts

2019-06-04

Expected to finish

2025-09-25

Last updated by the study team

2024-08-09

Who can join

Age: 7 and older, up to 12. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Pre-pubertal (e.g. Tanner stage 1 or 2)
• Age 7-12 inclusive
• Signed consent/assent
• Parent communicates sufficiently in English to provide informed consent and complete assessment instruments;
• ADHD as determined by computerized DISC (C-DISC) parent interview
• ADHD-Rating Scale-5 total score (interview with parent )
• SNAP ADHD total score (teacher) of 1.5 SD > age/sex norms
• CD or severe ODD: CD or ODD + 2 symptoms of CD on C-DISC
• SNAP ODD/CD subscale (parent and teacher) 1.5 SD > age/sex norms

You may not qualify if…

• Major neurological/medical illness
• History of head injury
• Fetal exposure to alcohol/drugs
• Diagnosis of major psychiatric disorder (e.g., schizophrenia, bipolar disorder, major depression, generalized anxiety, social phobia, Tourette's Disorder, PTSD, autism spectrum disorder)
• Current suicidal ideation or past history of suicide attempt
• Wechsler Abbreviated Scale of Intelligence (WASI)75 score <75
• Prior or current treatment with stimulants (prior or current treatment with non-stimulants is permitted, but participants must be off medication for 2 weeks at baseline)
• Current or past alcohol/drug use (DISC interview; urine toxicology)
• Psychological or medical condition which precludes being in the scanner (e.g., claustrophobia, morbid obesity)
• Metal in the body that cannot be removed (e.g., braces, metal plate)
• Visual disturbances that may impair task performance
• Precocious puberty (e.g. Tanner stage >2) or pregnancy
• Notes:
• History of SUD in a 1st degree relative is permitted, and is expected in \~1/2 of the subjects
• Ongoing psychosocial treatment is allowed but should not be initiated during the study

Where it is running

• Icahn School of Medicine at Mount Sinai — New York, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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