DOAC in Unusual Site Venous Thrombosis
Completed
Conditions studied: Splanchnic Vein Thrombosis, Cerebral Vein Thrombosis, Ovarian Vein Thrombosis, Renal Vein Thrombosis, Retinal Vein Thrombosis
In brief
Unusual site venous thromboembolism (VTE) refers to thrombosis occurring in venous districts outside the veins of the lower extremities and the pulmonary arteries, and includes splanchnic vein thrombosis (SVT), cerebral vein thrombosis (CVT), retinal vein thrombosis, ovarian vein thrombosis, and renal vein thrombosis. The use of the novel direct oral anticoagulants (DOAC), thrombin or factor Xa-inhibitors (such as dabigatran, apixaban, edoxaban, rivaroxaban), in patients with unusual VTE in clinical practice is increasing. Through an international multicentre prospective registry, the investigators aim to evaluate the rationale for the use of the DOAC for the treatment of unusual site VTE and to assess the safety and effectiveness of this approach in real life clinical practice.
Key facts
- Study ID
- NCT03778502
- Run by
- University of Malta
- People needed
- 358
- Starts
- 2019-10-01
- Expected to finish
- 2024-12-31
- Last updated by the study team
- 2025-07-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Objective diagnosis of venous thrombosis not involving the upper limbs, lower limbs and pulmonary arteries
- Treatment with one of the DOAC (e.g. apixaban, dabigatran, edoxaban, rivaroxaban)
You may not qualify if…
- Enrolment in interventional studies evaluating the DOAC for the treatment of unusual site VTE
Where it is running
- Henry Ford Health System — Detroit, Michigan, United States
- Ottawa Hospital Research Institute — Ottawa, Canada
- CHU Amiens Picardie — Amiens, France
- Hôpital de la Cavale Blanche — Brest, France
- Hôpital Edouard Herriot — Lyon, France
- Hopital Louis Mourier — Paris, France
- Hôpital Européen Georges Pompidou — Paris, France
- Centre Hospitalier Universitaire de Saint-Etienne — Saint-Etienne, France
- Sheba medical center — Tel Litwinsky, Israel
- Azienda Ospedaliera Universitaria di Bologna — Bologna, Italy
- Ospedale Maggiore, Bologna — Bologna, Italy
- Ospedale Sant'Anna, ASST Lariana — Como, Italy
- Ospedale Policlinico San Martino — Genova, Italy
- Ospedale San Paolo — Milan, Italy
- University Hospital of Padova — Padova, Italy
- Catholic University — Rome, Italy
- Sapienza Università di Roma — Rome, Italy
- University of Insubria — Varese, Italy
- University of Malta — Msida, Malta
- Radboud University Medical Center Nijmegen — Nijmegen, Netherlands
- University Medical Centre Ljubljana — Ljubljana, Slovenia
- Clinica Universidad de Navarra — Madrid, Spain
- Virgen del Rocío Hospital and Instituto de Biomedicina — Seville, Spain
- King Chulalongkorn Memorial Hospital — Bangkok, Thailand
Full record on ClinicalTrials.gov
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