Mass Accumulation Rate (MAR) as a Predictive Biomarker in Multiple Myeloma

Stopped early

Conditions studied: Multiple Myeloma in Relapse

In brief

This study will collect bone marrow (BM) aspirate samples from patients with relapsed refractory multiple myeloma (RRMM) prior to the start of a new treatment regimen for the purposes of prospectively measuring single-cell mass accumulation rate (MAR) as a biomarker of patient response to that regimen. The primary study objective is to explore whether the single-cell MAR biomarker can predict patient response in RRMM patients. In order to enable this primary objective, two patient cohorts will be required. First, a small vanguard cohort of patients with treatment naïve disease to define drug concentrations used for testing, and second, the main RRMM patient cohort. Data will be collected to estimate the biomarker's predictive properties (accuracy, sensitivity, specificity), and to support improvement of the MAR biomarker through additional research and discovery within the study dataset.

Key facts

Study ID

NCT03777410

Run by

Travera Inc

People needed

33

Starts

2019-02-11

Expected to finish

2024-06-30

Last updated by the study team

2024-07-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Written Informed Consent provided by patient
• MM, with the following conditions:
• (CLOSED) *For patients in the Vanguard cohort*
• Treatment naïve disease with BM clinically indicated
• For patients in the RRMM cohort*
• Relapsed/refractory disease with BM samples clinically indicated
• Within 4-weeks prior to initiation of 2nd-line or later therapy
• Patient's oncologist must be planning to change the patient's next line of treatment to a monotherapy or combination therapy composed exclusively of drugs from the following list: Bortezomib (Velcade), Carfilzomib (Kyprolis), Lenalidomide (Revlimid), Pomalidomide (Pomalyst), Cyclophosphamide (Cytoxan), Dexamethasone, Ixazomib (Ninlaro), Venetoclax (Venclexta), Selinexor (Xpovio)

You may not qualify if…

• Unable or unwilling to provide informed consent
• Daratumumab/Elotuzumab or other antibody-based therapeutic regimens as immediately planned treatment (as prior therapy is acceptable)
• Patient enrolled/enrolling in a clinical trial where data or specimen sharing provisions preclude use in this study
• Prior exposure to CAR-T therapy
• Prior allogeneic stem cell transplant
• Has received any systemic chemotherapy or RT, including palliative, within 7 days prior to BM biopsy
• Has received any Ab therapy within 4 weeks prior to BM biopsy

Where it is running

• City of Hope Comprehensive Cancer Center — Duarte, California, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Dana-Farber Cancer Institute — Boston, Massachusetts, United States
• Weill Cornell Medicine - New York Presbyterian — New York, New York, United States

Full record on ClinicalTrials.gov

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