The Effect of Transcutaneous Magnetic Stimulation on Acute Pain.
Withdrawn before enrolling · Has a placebo group
Conditions studied: Pain Perception
In brief
This is a single institution, single-blinded, long-term exploratory study using participant as his/her own control to evaluate and compare the potential analgesic effect on experimental heat pain of Transcutaneous Magnetic Stimulation (TMS). TMS will be delivered by a commercially available device (Rapid2, Magstim Corp) at three different cortical target sites and one sham target site in healthy participants 18-88 years of age. The quantitative evaluation measure is the change in the painful heat threshold Quantitative Sensory Testing (QST) of thresholds for cutaneous heat stimuli before and after TMS.
Key facts
- Study ID
- NCT03777137
- Run by
- Johns Hopkins University
- People needed
- 0
- Starts
- 2021-10-01
- Expected to finish
- 2027-07-01
- Last updated by the study team
- 2021-10-14
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy man or woman 18-80 years of age;
- Possess the ability to understand study procedures and comply with them for the entire length of the study;
- Women of childbearing age must use contraception for duration of study.
You may not qualify if…
- History of diagnosis of heart disease, increased intracranial pressure, or structural abnormalities of the brain (e.g. tumor);
- History of epilepsy, seizure disorder, neurologic disease, cranial trauma or head surgery, or implanted hardware (including cardiac pacemakers, cardiac lines, medication pumps, or stimulators);
- Family history of seizures;
- Presence of metal anywhere deep to or on the skull (excluding the mouth);
- Any current or recent (<6 weeks) or planned (within duration of study period) use of any of the following medications: imipramine, amitriptyline, doxepin, nortriptyline, maprotiline, chlorpromazine, clozapine, foscarnet, ganciclovir, ritonavir, amphetamines, ketamine, gamma-hydroxybutyrate (GHB), and theophylline;
- History of peripheral neuropathy, e.g. Diabetic Neuropathy;
- Women who are pregnant or women of childbearing capacity who may become pregnant (i.e. not using contraception);
- Volunteers with communication disorders or non-English speakers;
- Current drug or alcohol use or dependence that, in the opinion of the investigators, would interfere with adherence to study requirements.
Where it is running
- Hopkiins Functional Neurosurgery Lab — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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