Bioavailability of Phytonutrients From Novel Preparations of Broccoli

Completed · Not applicable

Conditions studied: Healthy Volunteers

In brief

The primary objective of this study is to determine the effects of different methods of broccoli preparation on levels of urinary glucosinolate metabolites. The secondary objective is to determine the effects of different methods of broccoli preparation on levels of plasma carotenoids.

Key facts

Study ID

NCT03773497

Run by

USDA Beltsville Human Nutrition Research Center

People needed

16

Starts

2019-04-16

Expected to finish

2019-06-28

Last updated by the study team

2019-09-03

Who can join

Age: 21 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Between 21 and 75 years old at beginning of study

You may not qualify if…

• Pregnant, lactating, or intending to become pregnant during the study period
• Women who have given birth during the previous 12 months
• Presence of kidney disease, liver disease, gout, certain cancers, gastrointestinal disease, hyperthyroidism, untreated or unstable hypothyroidism, pancreatic disease, other metabolic diseases, or malabsorption syndromes requiring special diets
• History of certain cancers within last 3 years
• Known allergy or intolerance to Brassica vegetables
• History of eating disorders or other dietary patterns which are not consistent with the dietary intervention (e.g., vegetarians, very low-fat diets, high-protein diets)
• Colonoscopy during three weeks prior to start of study
• Unwillingness to abstain from probiotics or vitamin, mineral, herbal and glucosinolate/isothiocyanate supplements for two weeks prior to the study and during the study
• Use of tobacco products within 6 months preceding study
• Crohn's disease or diverticulitis
• Suspected or known strictures, fistulas or physiological/mechanical GI obstruction
• Use of certain medications (prescription or over-the-counter) that may interfere with the study objectives
• Type 2 diabetes requiring the use of diabetes pills, insulin, or non-insulin shots
• Fasting glucose greater than or equal to 126 mg/dL
• Unable or unwilling to give informed consent or communicate with study staff
• Self-report of alcohol or substance abuse within the past 12 months and/or current treatment for these problems (long-term participation in Alcoholics Anonymous is not an exclusion)
• Other medical, psychiatric, or behavioral factors that in the judgment of the Principal Investigator may interfere with study participation or the ability to follow the intervention protocol

Where it is running

• USDA-ARS Beltsville Human Nutrition Research Center — Beltsville, Maryland, United States

Full record on ClinicalTrials.gov

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