Primary Cytoreductive Surgery With or Without Hyperthermic Intraperitoneal Chemotherapy (HIPEC)

Running, not enrolling · Phase 3

Conditions studied: Ovarian Cancer

In brief

stage III epithelial ovarian cancer randomizing between primary cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy

Key facts

Study ID

NCT03772028

Run by

The Netherlands Cancer Institute

People needed

538

Starts

2020-01-01

Expected to finish

2028-12-01

Last updated by the study team

2026-04-08

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• candidate for primary CRS
• histological or cytological proven FIGO stage III primary epithelial ovarian, fallopian tube, or extra-ovarian cancer

You may not qualify if…

• history of previous malignancies within 5 years prior to inclusion
• FIGO stage IV disease
• complete primary cytoreduction is impossible
• prior treatment for the current malignancy

Where it is running

• City of Hope — Duarte, California, United States
• MSKCC New York — New York, New York, United States
• Rigshospitalet Copenhagen — Copenhagen, Denmark
• CHU de Besancon — Besançon, France
• Institut Bergonié — Bordeaux, France
• o Institut Bergonié, Bordeaux — Bordeaux, France
• CHU Lille — Lille, France
• Centre Leon Berard, Lyon — Lyon, France
• CHU Lyon — Lyon, France
• Institut du Cancer Montpellier — Montpellier, France
• Institut de Cancerologie de l'Ouest, ICO Nantes) — Nantes, France
• Institut Curie Paris — Paris, France
• CHRU Strasbourg — Strasbourg, France
• Oncopole, Institute Universitaire du Cancer de Toulouse (IUCT Toulouse) — Toulouse, France
• Mater Misericordiae University Hospital, Dublin — Dublin, Ireland
• Policlinico Sant'Orsola, Bologna — Bologna, Italy
• Fondazione Policlinico A Gemelli IRCCS — Roma, Italy
• Antoni van leeuwenhoek — Amsterdam, North Holland, Netherlands
• Amsterdam UMC — Amsterdam, Netherlands
• Catharina Hospital — Eindhoven, Netherlands
• Medisch Spectrum Twente — Enschede, Netherlands
• UMCG — Groningen, Netherlands
• Leiden University Medical Center (LUMC) — Leiden, Netherlands
• Maastricht UMC+ — Maastricht, Netherlands
• Radboud MC — Nijmegen, Netherlands

Full record on ClinicalTrials.gov

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