Resistance Exercise and Low-Intensity Physical Activity Breaks in Sedentary Time to Improve Muscle and Cardiometabolic Health
Completed · Not applicable
Conditions studied: Aging, Sarcopenia, Disability Physical, Cardiovascular Diseases, Insulin Resistance, Diabetes Mellitus
In brief
What are the effects of resistance exercise (RE) alone or RE plus low intensity physical activity (LPA) breaks in sedentary time (ST) on skeletal muscle health in older adults? What are the effects of resistance exercise (RE) alone or RE plus low intensity physical activity (LPA) breaks in sedentary time (ST) on skeletal cardiometabolic health in older adults?
Key facts
- Study ID
- NCT03771417
- Run by
- Louisiana State University and A&M College
- People needed
- 24
- Starts
- 2019-01-16
- Expected to finish
- 2023-02-09
- Last updated by the study team
- 2025-03-19
Who can join
Age: 65 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Are capable and willing to give written informed consent, and understand exclusion criteria
- 65-80 years of age inclusive
- Body Mass Index (BMI) between 18.5-34.9 kg/m2, inclusive
- Physically inactive determined by self-report
- Stable medical therapy for allowable medications for 30 days defined as:
- No addition or removal of a medication
- No change in dosage of a medication
- Having no life-threatening conditions or diseases
- Willing to allow researchers to use data, bio-specimens (blood and muscle tissue), and images (e.g., magnetic resonance imaging) for research purposes after study participation is completed
- At least 2 weeks post-completion of the COVID19 vaccine regimen. a. Acceptable proof of vaccine includes a completed vaccine card and/or letter from a healthcare provider indicating the date that the COVID19 vaccine was completed.
You may not qualify if…
- Nursing home resident
- Physically Active:
- a. > 100 min/wk of moderate OR > 50 min/wk vigorous intensity PA
- Saint Louis University Mental State (SLUMS) score < 21
- Evidence or self-report history of deep vein thrombosis, pulmonary embolism, cardiovascular, peripheral vascular, cerebral vascular, pulmonary, or renal disease
- Evidence or self-report history of type 1 or 2 diabetes mellitus
- Evidence or self-report history of a bleeding disorder
- Evidence or self-report history of recurrent vasovagal episodes
- Evidence or self-report history of severe depression, Schizophrenia, bipolar disease
- Evidence or self-report history of mobility disability requiring a walker, wheel chair, or inability to walk across a small room.
- Evidence or self-report history of orthopedic limitations that would preclude them from participation in a dynamic exercise program
- Evidence or self-report history of severe arthritis (either osteoarthritis or rheumatoid arthritis) that would preclude them from participation in a dynamic exercise program
- Evidence or self-report of history untreated thyroid dysfunction.
- Weight loss of > 10% in the last 3 months prior to screening
- History of weight loss surgery.
- Use of medications known to influence study outcomes, such as:
- Insulin
- Oral antidiabetic medications (e.g., metformin)
- Corticosteroids
- Beta-blockers
- c. Anticoagulants
- Allergy to lidocaine
- Active smoking
- Current consumption of > 14 alcoholic drinks per week based on self-report
- Regular participation in resistance or aerobic exercise training within 3 months of initial screening
Where it is running
- Lousiana State University — Baton Rouge, Louisiana, United States
- Pennington Biomedical Research Center — Baton Rouge, Louisiana, United States
Full record on ClinicalTrials.gov
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