The Impact of Phosphate Metabolism on Healthy Aging
Recruiting now · Early Phase 1
Conditions studied: Hypophosphatemia, Rickets, Hypercalciuria, XLH, HHRH
In brief
Determine the association between duration and dose of chronic conventional therapy with Pi and renal (nephrocalcinosis/nephrolithiasis), vascular (endothelial function), and cardiovascular function (echo- cardiography) in patients with hereditary hypophosphatemic rickets with hypercalciuria (HHRH) and patients with X-linked hypophosphatemia (XLH).
Key facts
- Study ID
- NCT03771105
- Run by
- Yale University
- People needed
- 30
- Starts
- 2019-01-01
- Expected to finish
- 2028-04-01
- Last updated by the study team
- 2026-05-27
Who can join
Age: 13 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Children above the age of 13 years
- Younger and older adults with XLH and HHRH with confirmed NPT2c mutations affecting both copies of the NPT2c gene (HHRH) or one copy of the PHEX gene (XLH)
- Be willing to provide access to prior medical records to determine eligibility including imaging, biochemical, medical, and surgical history data
- Be willing and able to complete all aspects of the study
- Be willing to adhere to the study visit schedule and comply with the assessments (in the opinion of the investigator).
You may not qualify if…
- Subjects will be excluded, if they are children younger than age 13 years
- Subjects that have other diseases likely to impact bone and mineral metabolism (e.g. renal, hepatic, gastrointestinal disorders, and malignancy),
- Subjects that are currently pregnant,
- Subjects that received medical therapy or developed any condition, which in the opinion of the investigator, could present a concern for either subject safety or difficulty with data interpretation.
- Subjects will be excluded from Aim 2, if they are unable to tolerate supplemental phosphate.
Where it is running
- Yale University School of Medicine — New Haven, Connecticut, United States (enrolling)
Full record on ClinicalTrials.gov
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