Molecular Genetic, Host-derived and Clinical Determinants of Long-term Survival in Glioblastoma

Completed

Conditions studied: Glioblastoma

In brief

This pro - and retrospective multicenter clinical epidemiological study studies the molecular genetic, host-derived and clinical determinants of glioblastoma patients with an overall survival of more than 5 years. The different research focusses are: * Identification of clinical parameters and patient characteristics / host-related factors in long-term survivors (Focus 1) * Identification of molecular tumor characteristics in long-term survivors (Focus 2) * Assessment of therapy-related parameters, including neuro-toxicity (Focus 3) * Immunological studies (Focus 4)

Key facts

Study ID

NCT03770468

Run by

European Organisation for Research and Treatment of Cancer - EORTC

People needed

599

Starts

2015-07-05

Expected to finish

2023-08-18

Last updated by the study team

2024-03-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age > 18 years at diagnosis
• Histopathological diagnosis of glioblastoma (reference histology available) and
• Survival >5 years from diagnosis
• Availability of tumor tissue from initial glioblastoma diagnosis (FFPE or fresh-frozen) to validate the diagnosis centrally.
• Signed consent form (living patients) or ethics approval for anonymous data collection in case of retrospective analysis of deceased patients

You may not qualify if…

• Not applicable

Where it is running

• Dana-Farber Cancer Institute & Harvard Medical School — Boston, Massachusetts, United States
• Universitaetsklinikum Wien - AKH uniklinieken — Vienna, Austria
• Hopitaux Universitaires Bordet-Erasme — Brussels, Belgium
• CHU Lyon - Hopital neurologique Pierre Wertheimer — Bron, France
• CHRU de Lille — Lille, France
• Hopitaux de Marseille - Hôpital de La Timone (APHM) — Marseille, France
• Institut du Cancer de Montpellier — Montpellier, France
• CHU de Nice - Hopital Pasteur — Nice, France
• Hopitaux de Paris - Hopital Saint-Louis — Paris, France
• Hopitaux de Paris - La Pitie Salpetriere — Paris, France
• CHU d'Amiens - CHU Amiens - Hopital Sud — Salouël, France
• Universitaetsklinikum Bonn — Bonn, Germany
• Universitaetsklinikum Carl Gustav Carus — Dresden, Germany
• Universitaetsklinikum - Essen — Essen, Germany
• Ronellenfitsch Michael — Frankfurt, Germany
• Universitaetsklinikum Freiburg — Freiburg im Breisgau, Germany
• UniversitaetsKlinikum Heidelberg — Heidelberg, Germany
• Ludwig-Maximilians-Universitaet Muenchen - Campus Grosshadern — München, Germany
• Technische Universitaet Muenchen - Klinikum Rechts Der Isar — München, Germany
• Universitaetsklinikum Regensburg — Regensburg, Germany
• Hygeia Hospital — Athens, Greece
• Azienda Ospedaliera Di Padova - Istituto Oncologico Veneto IRCCS — Padova, Italy
• Azienda Ospedaliera Città della Salute e della Scienza di Torino - Ospedale San Giovanni — Torino, Italy
• Amsterdam UMC - locatie VUmc — Amsterdam, Netherlands
• Erasmus MC — Rotterdam, Netherlands

Full record on ClinicalTrials.gov

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