Levoketoconazole Food Effect Study in Healthy Subjects

Completed · Phase 1

Conditions studied: Healthy Subjects

In brief

This is a phase I, randomized, open-label, single-dose, two-period, two-sequence crossover study in healthy male and female subjects to evaluate the effect of food on the PK of levoketoconazole.

Key facts

Study ID

NCT03768388

Run by

Cortendo AB

People needed

22

Starts

2018-11-30

Expected to finish

2018-12-24

Last updated by the study team

2019-02-04

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Subject is 18-55 years of age, inclusive, at time of consent.
• Subject has a body mass index (BMI) between 18 and 32 kg/m2, inclusive.
• Subject is in good general physical health as determined by absence of clinically significant medical history, physical examination findings, vital signs, clinical laboratory evaluations, and ECG measurements.
• Subject has not consumed and agrees to abstain from taking any prescription drugs, dietary supplements including vitamins and herbal preparations, or non-prescription drugs (except as authorized by the Investigator AND Medical Monitor) for 14 days prior to CRU admission, during washout period, and through Follow-Up.
• Subject has not consumed alcohol-containing beverages for 3 days prior to CRU admission and agrees not to consume alcohol through Follow-Up.
• Subject is a nonsmoker (for at least 3 months) with negative urinary cotinine test at Screening and agrees to abstain from tobacco- and nicotine-containing products for the duration of the study.

You may not qualify if…

• Evidence of any out-of-normal-range laboratory value at Screening that has not been reviewed, approved, and documented as Not Clinically Significant by the Investigator.
• Concurrent medical illness that would interfere with the conduct of the study in the opinion of the Investigator.
• History or presence of clinically significant cardiovascular, pulmonary, hematologic, endocrine, immunologic, dermatologic, neurologic, psychiatric, renal, hepatic, chronic respiratory, or gastrointestinal disease as judged by the Investigator.
• Positive urine drug screen for drugs-of-abuse, including cocaine, tetrahydrocannabinol, opioids, benzodiazepines, amphetamines, and barbiturates, and/or positive urine screen for alcohol at Screening and CRU admission.
• Treatment with an investigational drug within the longer of 30 days or five half-lives of the investigational drug preceding the first dose of study drug.
• Subject is positive for Human Immunodeficiency Virus (HIV), hepatitis B, and/or hepatitis C on Screening assessments.
• Subject has an acute illness within 7 days of CRU admission.
• Subject has donated plasma within 7 days of drug administration.
• Subject has donated 1 or more pints of blood (or equivalent blood loss) within 30 days prior to drug administration.
• History of caffeine consumption exceeding 8 cups of coffee/day (1 cup = 8 fluid ounces) within 14 days prior to first dose, or consumption of any caffeine- or chocolate-containing products for 3 days prior to CRU admission each week. Caffeine-containing foods and/or beverages (e.g., tea and cola) should be considered equivalent to coffee.
• Female subjects who are pregnant or lactating.
• Males with hemoglobin less than 12.0 g/dL; Females with hemoglobin less than 11.0 g/dL.
• Subjects who have had difficulties with swallowing whole tablets.
• Subjects with body habitus preventing repeated venipuncture as required by protocol.

Where it is running

• Clinical Pharmacology of Miami, LLC — Miami, Florida, United States

Full record on ClinicalTrials.gov

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