Study of RP1 Monotherapy and RP1 in Combination With Nivolumab (IGNYTE)
Running, not enrolling · Phase 2
Conditions studied: Non-Small Cell Lung Cancer (NSCLC), Microsatellite Instability-High (MSI-H), Non-melanoma Skin Cancer (NMSC), Cutaneous Melanoma
In brief
The Phase 2 study is a multicenter, open-label study of RP1 to further investigate safety and to estimate the efficacy of RP1 at the RP2D in combination with nivolumab in patients with Stage IIIb-IV unresectable melanoma, microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) solid tumors, non-melanoma skin cancer (NMSC), and non-small cell lung cancer (NSCLC).
Key facts
- Study ID
- NCT03767348
- Run by
- Replimune, Inc.
- People needed
- 340
- Starts
- 2017-09-20
- Expected to finish
- 2028-12-01
- Last updated by the study team
- 2026-02-13
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Southern California — Los Angeles, California, United States
- UCLA — Los Angeles, California, United States
- University of California, Irvine — Orange, California, United States
- University of California- San Francisco — San Francisco, California, United States
- Sylvester Comprehensive Cancer Center- University of Miami — Miami, Florida, United States
- University of Iowa-Cancer Center Research — Iowa City, Iowa, United States
- James Graham Brown Cancer Center- University of Louisville — Louisville, Kentucky, United States
- Mayo Clinic — Rochester, Minnesota, United States
- New York University Clinical Cancer Center — New York, New York, United States
- Weill Cornell Medical College — New York, New York, United States
- University of Rochester Medical Center — Rochester, New York, United States
- Duke Cancer Center — Durham, North Carolina, United States
- University of Cincinnati Medical Center — Cincinnati, Ohio, United States
- Providence Portland Medical Center — Portland, Oregon, United States
- MUSC Health — Charleston, South Carolina, United States
- West Cancer Center — Germantown, Tennessee, United States
- The University of Texas MD Anderson Cancer Center — Houston, Texas, United States
- Eccles Outpatient Care Center- Oncology Clinical Trials — Murray, Utah, United States
- Intermountain Cancer Center- Saint George Cancer Center — St. George, Utah, United States
- Seattle Cancer Care Alliance- University of Washington — Seattle, Washington, United States
- University of Wisconsin-Carbone Cancer Center — Madison, Wisconsin, United States
- CHU Besancon - Hopital Jean Minjoz — Besançon, France
- Institut Bergonié — Bordeaux, France
- CHU Dijon — Dijon, France
- UC San Diego — La Jolla, California, United States
Full record on ClinicalTrials.gov
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