A Study on BMS-986177 for the Prevention of a Stroke in Patients Receiving Aspirin and Clopidogrel

Completed · Phase 2 · Has a placebo group

Conditions studied: Acute Ischemic Stroke, Transient Ischemic Attack (TIA)

In brief

The purpose of this clinical study is to determine whether the addition of an oral Factor XIa Inhibitor to Aspirin and Clopidogrel is more effective than standard therapy in secondary stroke prevention.

Key facts

Study ID

NCT03766581

Run by

Bristol-Myers Squibb

People needed

2366

Starts

2019-01-27

Expected to finish

2022-03-31

Last updated by the study team

2023-06-12

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male and Female ≥40 years of age
• Acute Ischemic Stroke or Transient Ischemic Attack
• Intracranial or Extracranial Atherosclerotic Plaque proximal to the affected brain area

You may not qualify if…

• Predicted inability to swallow study medication
• Any condition that, in the opinion of the Investigator, contraindicates anticoagulant therapy or would have an unacceptable risk of bleeding
• Use of thrombolytic therapy or mechanical thrombectomy for treatment of index stroke
• Other protocol defined inclusion/exclusion criteria could apply

Where it is running

• Local Institution - 0007 — Glendale, California, United States
• Local Institution - 0006 — Long Beach, California, United States
• Kaiser Permanente Los Angeles Medical Center — Los Angeles, California, United States
• Local Institution - 0231 — Los Angeles, California, United States
• Local Institution - 0376 — Sacramento, California, United States
• Local Institution - 0004 — Stanford, California, United States
• Local Institution - 0042 — Torrance, California, United States
• Local Institution - 0340 — Newark, Delaware, United States
• Local Institution - 0075 — Gainesville, Florida, United States
• Local Institution - 0013 — Sarasota, Florida, United States
• Local Institution - 0024 — Tampa, Florida, United States
• Local Institution - 0015 — Augusta, Georgia, United States
• Local Institution - 0428 — Honolulu, Hawaii, United States
• Local Institution - 0293 — Chicago, Illinois, United States
• University of Illinois Hospital & Health Sciences System — Chicago, Illinois, United States
• Local Institution - 0430 — Elk Grove Village, Illinois, United States
• Local Institution - 0382 — Rockford, Illinois, United States
• Local Institution - 0346 — Louisville, Kentucky, United States
• Local Institution - 0047 — New Orleans, Louisiana, United States
• Local Institution - 0420 — Baltimore, Maryland, United States
• Local Institution — Boston, Massachusetts, United States
• Local Institution - 0236 — Boston, Massachusetts, United States
• Local Institution — Detroit, Michigan, United States
• Local Institution - 0434 — Detroit, Michigan, United States
• Local Institution - 0029 — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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