Rescuing the Ruminating Brain: Identifying Biomarkers of Rumination and Mindfulness Through Concurrent EEG and Functional Magnetic Resonance Imaging (fMRI) Studies of Schizophrenia and Depression

Withdrawn before enrolling

Conditions studied: Schizophrenia, Depressive Disorder, Major

In brief

The investigators will acquire simultaneous EEG and fMRI data from Veterans with depression and schizophrenia and mentally healthy Veterans to assess early sensory responses, context updating, and responses to emotional images. Understanding how rumination affects engagement with the environment is the first step towards assessing its far-reaching cognitive and emotional costs, which cut across traditional diagnostic boundaries. Understanding how mindfulness restores information processing will increase our understanding of how, and for whom, it works.

Key facts

Study ID

NCT03758495

Run by

VA Office of Research and Development

People needed

0

Starts

2018-11-01

Expected to finish

2018-11-02

Last updated by the study team

2019-01-10

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• (All)
• Veterans
• 18-65 years of age
• Negative metal screen for MR scanning
• Corrected to normal vision
• Inclusion Criteria (patients):
• Meet criteria for SZ or MDD as assessed using the Structured Clinical Interview for DSM (SCID), with a consensus diagnosis between trained research staff member and an attending psychiatrist or psychologist.
• Stable medication regime for > 1 month

You may not qualify if…

• (All)
• Past or present neurological problems (including seizures and head trauma resulting in neurological or cognitive sequelae)
• Loss of consciousness (LOC) greater than 30 minutes or any LOC with neurologic sequelae
• Major medical conditions (e.g., significant hypertension, diabetes not controlled by diet alone, seizure disorders, treatment with anticonvulsant medication, endocrine disorders, significant cardiac pathology)
• Substance abuse within three months of participation or any history of substance dependence
• History of HIV risk behaviors
• Known claustrophobia
• Pregnancy. If the participant cannot rule out pregnancy, a pregnancy urine test will be conducted moments before scanning.
• Uncorrected vision as assessed by the Snellen chart.
• Exclusion criteria (patients only):
• Any primary Diagnostic and Statistical Manual Diploma in Social Medicine (DSM) Axis I diagnosis other than SZ or MDD
• Exclusion criteria (controls only):
• Any past or present DSM Axis I diagnosis
• Chronic treatment with medication that affects cognitive function

Where it is running

• San Francisco VA Medical Center, San Francisco, CA — San Francisco, California, United States

Full record on ClinicalTrials.gov

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