The Effect of InTensive Statin in Ischemic Stroke With inTracranial Atherosclerotic Plaques

Recruiting now · Phase 4

Conditions studied: Stroke, Ischemic, Atherosclerosis, Cerebral

In brief

Intracranial atherosclerotic disease is the most common cause of ischemic stroke that is directly attributed to the progression or rupture of intracranial high-risk plaque in Asia. Many studies mainly from Euro-American population with a focus on extracranial carotid plaque have fully demonstrated the advantages of intensive statin therapy on stabilizing or reversing plaque burden, reversing plaque composition presenting that lipid-rich necrotic core (LRNC) is gradually replaced by fibrous tissue, and even reversing pattern of arterial remodeling to reduce the occurrence of cerebrovascular events. Yet, direct evidence of the effect of intensive statin therapy on intracranial atherosclerotic plaques is lacking and the effect of statin intensity and duration on intracranial plaque burden and composition is still unclear. High resolution magnetic resonance imaging (HRMRI) is a new and non-invasive technique that enable to assess the morphologic characteristics of vascular wall and plaque composition of intracranial artery. Based on above discussion, the investigators conduct this study to further determine the effect of intensive statin in ischemic stroke with intracranial atherosclerotic plaques.

Key facts

Study ID

NCT03753555

Run by

General Hospital of Shenyang Military Region

People needed

100

Starts

2018-12-01

Expected to finish

2027-11-30

Last updated by the study team

2026-04-27

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient age between 18-80 years
• Time of onset: within 1 week
• NIHSS score ≤12
• Acute ischemic stroke confirmed by head CT or MRI
• Premorbid mRS ≤1
• The degree of stenosis of carotid artery, vertebral artery and intracranial portion of internal carotid artery on the lesion side <50%
• The culprit plaque or possible culprit plaque with plaque burden of 40% or more found by HRMRI in the proximal part of the middle cerebral artery M1 segment or basilar artery of ipsilateral lesion
• Signed informed consent

You may not qualify if…

• Intracranial hemorrhage found by head CT
• Stroke attributable to cardioembolic origin (atrial fibrillation, valvular heart disease, aortic arch atherosclerosis)
• Severe hepatic or renal dysfunction
• Pregnant females
• Abnormal elevation of creatine phosphokinase
• Expected stent angioplasty
• Blood sugar is out of control
• Receiving statins within 1 month before onset
• Obstinate hypertension with more than 140/90 mmHg after medication
• Not willing and able to comply with scheduled visits, lifestyle guidelines, treatment plan, laboratory tests, and other study procedures
• Unsuitable for this clinical studies assessed by researcher

Where it is running

• General Hospital of ShenYang Military Region — Shenyang, China (enrolling)

Full record on ClinicalTrials.gov

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