ENGAGE for Brain Health

Completed · Not applicable

Conditions studied: Motoric Cognitive Risk Syndrome

In brief

Age-related cognitive decline has a profound impact on the daily functioning of older adults, their families and healthcare systems. Despite its significant personal, societal and economic impact, no pharmacologic therapies presently exist to mitigate age-related cognitive decline. As the population of older adults continues to rapidly increase, the implementation of effective and scalable low-cost interventions that may maintain the cognitive independence of broad populations of older persons are now of urgent public health priority.

Key facts

Study ID: NCT03750682
Run by: Tufts University
People needed: 25
Starts: 2019-01-01
Expected to finish: 2020-11-27
Last updated by the study team: 2022-02-14

Who can join

Age: 60 and older, up to 89. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and Women age 60-89 years, community-dwelling, ambulatory
Presence of MCR syndrome
Sedentary (reporting ≤ 20 min/week of regularly structured physical activity in the past month)
Written permission from PCP for study participation
Willingness to be randomized and participate for 24 weeks

You may not qualify if…

• Acute or terminal illness
Modified Mini-Mental State Examination Score <80(<76 if African American)*
Myocardial Infarction in the previous 6 months
Symptomatic coronary artery disease
Upper or lower extremity fracture in the previous 6 months
Resting blood pressure >180/100 mmHg
Unable to communicate due to severe hearing loss or speech disorder
Severe visual impairment that may preclude participation in the study assessments or interventions
Non-English speaking

Where it is running

Jean Mayer Human Nutrition Research Center on Aging at Tufts University — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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