Clazakizumab for the Treatment of Chronic Active Antibody Mediated Rejection in Kidney Transplant Recipients

Stopped early · Phase 3 · Has a placebo group

Conditions studied: Antibody-mediated Rejection

In brief

This trial investigates the efficacy and safety of clazakizumab \[an anti-interleukin (IL)-6 monoclonal antibody (mAb)\] for the treatment of CABMR in recipients of a kidney transplant.

Key facts

Study ID

NCT03744910

Run by

CSL Behring

People needed

194

Starts

2019-10-14

Expected to finish

2024-04-08

Last updated by the study team

2025-07-23

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Mayo Clinic Hospital — Phoenix, Arizona, United States
• Keck Medical Center Of USC — Los Angeles, California, United States
• Cedars-Sinai Medical Center — Los Angeles, California, United States
• UCLA Kidney Transplant Research Program — Los Angeles, California, United States
• University of California Davis Medical Center — Sacramento, California, United States
• California Institute of Renal Research — San Diego, California, United States
• North America Research Institute — San Dimas, California, United States
• California Pacific Medical Center — San Francisco, California, United States
• Kaiser Permanente — San Francisco, California, United States
• University of California, San Francisco Medical Center — San Francisco, California, United States
• University Of Colorado Hospital - Anschutz Medical Campus — Aurora, Colorado, United States
• Tampa General Medical Group — Tampa, Florida, United States
• Northwestern Memorial Hospital — Chicago, Illinois, United States
• Rush University Medical Center - University Cardiovascular Surgeons — Chicago, Illinois, United States
• Indiana University (IU) Health Physicians - Kidney Diseases Clinic - Medical Diagnostic Center Location — Indianapolis, Indiana, United States
• Unity Point Health — Des Moines, Iowa, United States
• Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States
• University of Louisville Research Foundation — Louisville, Kentucky, United States
• Tulane University Health Sciences Center — New Orleans, Louisiana, United States
• Massachusetts General Cancer Center — Boston, Massachusetts, United States
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• Henry Ford Health System — Detroit, Michigan, United States
• University of Minnesota — Minneapolis, Minnesota, United States
• Mayo Clinic — Rochester, Minnesota, United States
• University of Alabama at Birmingham (UAB) - University of Alabama Hospital (UAB Hospital) — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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