Study of Surzebiclimab (BGB-A425) and Alcestobart (LBL-007) in Combination With Tislelizumab in Advanced Solid Tumors
Completed · Phase 1/Phase 2
Conditions studied: Locally Advanced or Metastatic Solid Tumors for Phase 1, Dose Escalation and Phase 2 Safety Lead-in, HNSCC for Phase 2 Dose Expansion, NSCLC for Phase 2 Dose Expansion
In brief
This was an open-label, multicenter, nonrandomized Phase 1 and 2 clinical trial evaluating various combinations of surzebiclimab (BGB-A425) and/or alcestobart (LBL-007) with tislelizumab.
Key facts
- Study ID
- NCT03744468
- Run by
- BeiGene
- People needed
- 147
- Starts
- 2018-11-13
- Expected to finish
- 2025-02-06
- Last updated by the study team
- 2026-04-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Chao Family Comprehensive Cancer Center — Orange, California, United States
- University of Colorado Cancer Center — Aurora, Colorado, United States
- University of Chicago Medical Center — Chicago, Illinois, United States
- University of Kentucky Markey Cancer Center — Lexington, Kentucky, United States
- Weill Cornell Medical College Newyork Presbyterian Hospital — New York, New York, United States
- University of North Carolina At Chapel Hill — Chapel Hill, North Carolina, United States
- Fox Chase Cancer Center — Philadelphia, Pennsylvania, United States
- The University of Texas Md Anderson Cancer Center — Houston, Texas, United States
- Ut Health San Antonio Mays Cancer Center — San Antonio, Texas, United States
- University of Virginia — Charlottesville, Virginia, United States
- Schar Cancer Institute — Fairfax, Virginia, United States
- Sydney Southwest Private Hospital — Liverpool, New South Wales, Australia
- Sunshine Coast Hospital and Health Service — Birtinya, Queensland, Australia
- Gold Coast University Hospital — Southport, Queensland, Australia
- Lyell McEwin Hospital — Elizabeth Vale, South Australia, Australia
- Calvary North Adelaide Hospital — North Adelaide, South Australia, Australia
- Box Hill Hospital — Box Hill, Victoria, Australia
- Cabrini Research and Education Institute — Malvern, Victoria, Australia
- Peter Maccallum Cancer Centre — Melbourne, Victoria, Australia
- Western Health Sunshine Hospital — St Albans, Victoria, Australia
- Hollywood Private Hospital — Nedlands, Western Australia, Australia
- Linear Clinical Research — Nedlands, Western Australia, Australia
- Centre de Lutte Contre Le Cancer Institut Bergonie — Bordeaux, France
- Centre de Lutte Contre Le Cancer Francois Baclesse — Caen, France
- Institut Curie Paris — Paris, France
Full record on ClinicalTrials.gov
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