Disorders of the Acute Phase Response Following Trauma and Invasive Surgery

Enrolling by invitation · Not applicable

Conditions studied: Acute Phase Response

In brief

The purpose of the proposed study is to test these hypotheses through the following aims: 1. To determine if early plasmin activation following severe injury correlates with SIRS, TIC and complications throughout convalescence in both trauma and surgical patients. 2. To determine if early plasmin activation following severe injury correlates with plasminogen consumption and poor plasmin activity later in convalescence.

Key facts

Study ID: NCT03741023
Run by: Vanderbilt University Medical Center
People needed: 320
Starts: 2019-12-12
Expected to finish: 2027-12-31
Last updated by the study team: 2026-03-27

Who can join

Age: 0 and older. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

None
Arm 2: Invasive Elective Surgical Patients Inclusion criteria
Any patient admitted for an invasive elective surgery associated with high blood loss or a high risk of vascular complications at VUMC/VCH. Enrollment will be at the discretion of the attending physician
This may include, but is not limited to, orthopedic and vascular surgery patients
Patients ages 2 months and older Exclusion criteria
None
Arm 3: Healthy Volunteers Inclusion criteria
Volunteers should be male or female
Age 18-70 years of age
Weight greater than 110lbs
Exclusion criteria
Chronic medical conditions such as: diabetes, hypertension, high cholesterol, rheumatologic disorders, infections, etc.
No history of recent traumatic injury (within the past year)
Pregnant females or people on hormone replacement therapy
People on any anticoagulant medication or NSAIDS

Where it is running

Vanderbilt Univeristy Medical Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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