Human Behaviors Related to the Expectation of Pain

Stopped early · Not applicable

Conditions studied: Fear Pain

In brief

The conditioned expectation of pain is an important aspect of pain-related disability produced by environments and stimuli associated with a painful injury on the job, although the neuroscience of this expectation is unclear. We will develop and use novel objective methods for measurement of expectation and threat related attention. The results of this study may lead to testable hypotheses regarding the psychological basis of the fear of pain, threat and task related attention. We will also use these results, and development of novel autonomic and ratings metrics for state and trait anxiety as well as threat and task related attention which could be used as an instrumented test for diagnosis and management of PTSD and anxiety disorders. .

Key facts

Study ID

NCT03739645

Run by

Johns Hopkins University

People needed

32

Starts

2020-08-01

Expected to finish

2023-10-01

Last updated by the study team

2025-05-25

Who can join

Age: 16 and older, up to 88. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Man or woman between 18 and 80 years of age.
• Fluent speaker of English.
• Undergoing seizure monitoring at Hopkins Hospital through intracranial electrodes.
• Possess ability to understand study procedures and comply with them for the entire length of the study;
• Women of childbearing age must use pharmacological contraception (oral or patch) for the duration of the study follow-up.

You may not qualify if…

• Inability or unwillingness of individual to give written informed consent. Presence of any neurological disease other than epilepsy which is unstable or is not optimally treated.
• Presence of a significant abnormality on routine neuropsychological testing.
• Presence of any medical or psychiatric disease which is unstable or is not optimally treated.
• Presence of an abnormal MRI scan except for Normal variants or Medial Temporal Sclerosis (altered pathology and MRI signal in temporal lobe).
• Women who are pregnant or women of childbearing capacity who may become pregnant (i.e. not using contraception).
• Presence of generalized seizures, or reflex seizures i.e. triggered by a sensory stimulus.
• Presence of a language or hearing impairment.
• Non-English speakers.

Where it is running

• Hopkins Epilepsy Monitoring Unit, Zayhed 12. — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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