Computerized Cognitive Training in MS

Completed · Not applicable

Conditions studied: Multiple Sclerosis, Cognitive Decline

In brief

WHO: 40 participants with a confirmed diagnosis of Multiple Sclerosis (MS) able to engage in moderate physical activity. WHY: The purpose of this study is to evaluate two computerized brain training tools, which include light physical activity, to see if they can help improve cognitive functions, such as memory and attention, for patients with MS. WHAT: Complete a set of tests (physical and cognitive) at baseline, wear a Fitbit Flex device at home for the duration of the study, 3 supervised sessions for 4 weeks at UCSF, one visit for physical and cognitive tests at one week after the final supervised session, and one final visit 6 months after the final supervised session. WHERE: 20 participants at the UCSF Weill Institute for Neurosciences (675 Nelson Rising Lane, San Francisco, CA); 20 participants at Lausanne University Hospital (Rue du Bugnon 46, 1005 Lausanne, Switzerland)

Key facts

Study ID

NCT03737825

Run by

University of California, San Francisco

People needed

2

Starts

2019-04-25

Expected to finish

2025-02-12

Last updated by the study team

2026-04-06

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age between 18 and 60 years
• Presence of subjective cognitive complain from patient
• Objective general cognitive impairment: paper-and-pencil Symbol Digit Modalities Test (SDMT) z-score < -0.5 at screening

You may not qualify if…

• Falls in the past 12 weeks as evaluated in the enrollment interview [Hopkins Falls Grading Scale (Grade >1)]
• Strong risk of falling, assessed using the miniBEST (score< 16)
• Psychiatric co-morbidity or anti-depressive or anxiolytic medication that has been changed over the 6 months preceding consideration for study enrollment
• Colorblindness
• Presence of clinically and/or radiologically confirmed relapses or disease progression in the past 12 weeks.
• Visual, mental, motor or brainstem Functional Systems Score (FSS) on the Expanded Disability Status Scale (EDSS) superior to 2.

Where it is running

• Weill Institute for Neurosciences, University of California, San Francisco — San Francisco, California, United States
• Lausanne University Hospital (CHUV) — Lausanne, Switzerland

Full record on ClinicalTrials.gov

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