Dose-finding Study of SPK-8016 Gene Therapy in Patients With Hemophilia A to Support Evaluation in Individuals With FVIII Inhibitors

Completed · Phase 1/Phase 2

Conditions studied: Adeno-Associated Virus (AAV), Blood Coagulation Disorder, Blood Coagulation Disorders, Inherited, Coagulation Protein Disorders, Factor VIII (FVIII), Factor VIII (FVIII) Deficiency, Factor VIII (FVIII) Gene, Factor VIII (FVIII) Protein, Genetic Diseases, Inborn, Genetic Diseases, X-Linked, Gene Therapy, Gene Transfer, Hematologic Diseases, Hemorrhagic Disorders, Recombinant, Vector, Inhibitors

In brief

SPK-8016 is in development for the treatment of patients with inhibitors to FVIII. This Phase 1/2, open-label, non-randomized, dose-finding study to evaluate the safety, efficacy, and tolerability of SPK-8016 in adult males with severe hemophilia A and no measurable inhibitor against FVIII.

Key facts

Study ID

NCT03734588

Run by

Spark Therapeutics, Inc.

People needed

4

Starts

2019-01-30

Expected to finish

2023-01-19

Last updated by the study team

2024-02-23

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Be male and ≥18 years of age;
• Have clinically severe hemophilia A, defined as:
• <1% (<1 IU/dL) endogenous FVIII activity levels as historically documented by a certified laboratory or screening data results; OR
• 1-2% (1-2 IU/dL) endogenous FVIII activity levels and > 10 bleeding events per year (in the last 52 weeks prior to screening); OR
• 1-2% (1-2 IU/dL) endogenous FVIII activity levels and on prophylaxis;
• Have had >150 exposure days (EDs) to any recombinant and/or plasma-derived FVIII concentrates or cryoprecipitates
• Have no prior history of hypersensitivity or anaphylaxis associated with any FVIII or IV immunoglobulin administration
• Have no measurable inhibitor against FVIII as assessed by central laboratory, have no confirmed history of clinically significant FVIII inhibitor, and no clinical signs or symptoms of decreased response to FVIII administration (Note: family history of inhibitors will not exclude study participation)
• Agree to use reliable barrier contraception after the administration of SPK-8016 until notified by the Investigator.

You may not qualify if…

• Have active hepatitis B or C
• Have significant underlying liver disease.
• Have serological evidence of HIV-1 or HIV-2 with CD4 counts ≤200/mm3. Participants who are HIV-positive and stable, with an adequate CD4 count (>200/mm3) and undetectable viral load, and are on an antiretroviral drug regimen are eligible to enroll
• Have detectable antibodies reactive with AAV-Spark capsid
• Have history of chronic infection or other chronic disease
• Have been dosed in a previous gene therapy research trial within the last 52 weeks or with an investigational drug within the last 12 weeks
• Any concurrent clinically significant major disease (such as liver abnormalities or type I diabetes) or other condition that, in the opinion of the Investigator and/or Sponsor, makes the subject unsuitable for participation in the study;
• Unable or unwilling to comply with the schedule of visits and study assessments described in the clinical protocol.

Where it is running

• Orthopaedic Institute for Children — Los Angeles, California, United States
• Illinois Bleeding and Clotting Disorders Institute — Peoria, Illinois, United States
• University of Michigan — Ann Arbor, Michigan, United States
• Mississippi Center for Advanced Medicine — Madison, Mississippi, United States
• Weill Cornell Medicine — New York, New York, United States
• Oregon Health & Science University — Portland, Oregon, United States
• Penn State Health — Hershey, Pennsylvania, United States
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
• Jefferson University Hospitals — Philadelphia, Pennsylvania, United States
• Hemophilia Center of Western Pennsylvania — Pittsburgh, Pennsylvania, United States
• Virginia Commonwealth University School of Medicine — Richmond, Virginia, United States

Full record on ClinicalTrials.gov

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