Platelet Rich Fibrin and Autologous Fibrin Glue

Withdrawn before enrolling · Not applicable

Conditions studied: Gingival Recession

In brief

Platelet-rich fibrin (PRF) and Autologous Fibrin Glue (AFG) are fibrin preparation derived from human blood samples and are used in regenerative dentistry. Aim: The aim of this study is to evaluate the level of root coverage using PRF (+) AFG with a coronally advanced flap (CAF) or PRF only with a CAF compared to a sub-epithelial connective tissue graft (CTG) with a CAF for treating Class 1 and 2 gingival recession defects. Additionally, to evaluate the level of keratinized tissue tissue thickness and width using PRF (+) AFG with a CAF or PRF only with a CAF compared to CTG with CAF for Class 1 and 2 gingival recession defects. Method: 48 patients with recession defects will be randomly divided into three different treatment groups. Treatment Group A (n=16) will consist of patients treated with PRF (+) AFG with a CAF, Group B (n=16) will consist of patients treated with PRF only with a CAF and Group C (n=16) will consits of patients treated with CTG with CAF as a control. Clinical measurements will be assessed at baseline and at 1 month and 6 months after the surgery. The clinical measurements that will be recorded, include probing depth, clinical attachment level, and gingval recession parameters. The gingival recession parameters include recession width, depth and thickness.

Key facts

Study ID

NCT03734458

Run by

University of California, San Francisco

People needed

0

Starts

2019-07-01

Expected to finish

2021-01-01

Last updated by the study team

2019-10-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and women aged 18 years or over
• Miller's Class 1 and Class 2 recession
• Localized gingival recession of 1-6mm present on 1 or 2 continuous single rooted teeth. Gingival recession is measured from the cemental-enamel junction (CEJ; a stable anatomical landmark on every tooth) to the gingival margin.

You may not qualify if…

• Current tobacco use (greater than 1 cigarette/week) or history of quitting < 5 years previously (self reported)
• Poor oral hygiene (plaque index of 2 or greater) or active periodontal disease (diagnosis of moderate chronic periodontal disease or greater)
• Currently taking aspirin, prescription blood thinners
• Type II diabetes with HbA1c greater than 7
• Immunosuppressed or any other systemic condition that would disqualify subject as an acceptable surgical candidate

Where it is running

• UCSF School of Dentistry — San Francisco, California, United States

Full record on ClinicalTrials.gov

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