A Study to Evaluate Safety, Tolerability and Preliminary Efficacy of FP-1305 in Cancer Patients (MATINS)
Completed · Phase 1/Phase 2
Conditions studied: Cancer
In brief
This is a first in human study to identify whether FP-1305 is suitable to use in humans. The previous pre-clinical studies have demonstrated that FP-1305 binds to a receptor known as CLEVER-1. CLEVER-1 has been shown to support tumour growth. No significant adverse events were witnessed in primates and the dose used will be 300 fold lower than the dose provided to primates which showed no toxicity. The patients with advanced melanoma, uveal melanoma, cholangiocarcinoma, gallbladder cancer, ER+ breast, gastric, ovarian, pancreatic, colorectal, liver or anaplastic thyroid cancer who have exhausted all licenced therapeutic options will die due to their disease. Based on the investigator's existing data CLEVER-1 is expressed in these tumour types. Inhibition of CLEVER-1 with FP-1305 may have an anti-tumour effect in these patients.
Key facts
- Study ID
- NCT03733990
- Run by
- Faron Pharmaceuticals Ltd
- People needed
- 216
- Starts
- 2018-12-03
- Expected to finish
- 2023-10-31
- Last updated by the study team
- 2025-04-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- The University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States
- Clinical Research Institute HUCH Ltd — Helsinki, Finland
- Oulu University Hospital — Oulu, Finland
- Tampere University Hospital — Tampere, Finland
- Turku University Hospital — Turku, Finland
- The Institut Gustave Roussy — Villejuif, France
- Erasmus University Medical Center Rotterdam — Rotterdam, Netherlands
- START Madrid - CIOCC Hospital HM Sanchinarro — Madrid, Spain
- The Royal Marsden NHS Foundation Trust — Sutton, Surrey, United Kingdom
- Queen Elizabeth Hospital Birmingham — Birmingham, United Kingdom
- The Christie NHS Foundation Trust — Manchester, United Kingdom
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.