Hypoxic Pulmonary Vasoconstriction Pilot Study

Completed · Phase 4

Conditions studied: Emphysema

In brief

The purpose of this study is to determine if the events leading to smoking-associated centrilobular and paraseptal emphysema are caused by a failure of the lungs' inherent mechanisms to block hypoxic pulmonary vasoconstriction (HPV) in areas of smoking-induced inflammation.

Key facts

Study ID

NCT03733470

Run by

Eric A. Hoffman

People needed

22

Starts

2011-06-29

Expected to finish

2014-01-13

Last updated by the study team

2019-10-01

Who can join

Age: 30 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Must be between the ages of 30 and 60.
• Must be currently smoking at least 1/2 pack/day (confirmed with cotinine level).
• Must have pulmonary function test (PFT) results that meet the following:
• Forced Expiratory Volume at one second (FEV1)/Forced Vital Capacity (FVC) > 70%
• Forced Expiratory Flow at 25-75% (FEF25-75) > 79% of predicted
• FVC greater than 80% of predicted
• Must be able to give informed consent for self.

You may not qualify if…

• Pregnant or breastfeeding females.
• Body Mass Index (BMI) greater than 32.
• Weight of greater than 220 pounds (100 kg).
• Allergies to shell fish, seafood, eggs or iodine.
• Heart disease, kidney disease or diabetes.
• Diagnosis of asthma.
• Usage of any medications that are known to affect the heart or lungs (contraceptives, anti-depressants, analgesics EXCEPT aspirin, antihypertensives, and medications for osteoporosis and gastrointestinal diseases will be allowed).
• Any metal in or on the body between the nose and the abdomen.
• Any major organ system disease (by judgment of study medical team).
• For the subjects that will receive Sildenafil as part of the study, additional exclusion criteria are as follows:
• Nitroglycerin usage.
• Prior history of hypersensitivity to Sildenafil.

Where it is running

• University of Iowa — Iowa City, Iowa, United States

Full record on ClinicalTrials.gov

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