Neuromodulation for Exercise Adherence

Completed · Not applicable · Has a placebo group

Conditions studied: Executive Dysfunction, Poor Exercise Adherence

In brief

Lack of adherence to an exercise program is a major problem for older Veterans. Several fall prevention programs fail in the home setting due to lack of adherence. Exercise adherence is dependent on brain function among other factors. Magnetic stimulation of the front part of the brain improves brain function necessary for planning and following-through. The investigators propose a three-phase study in 106 sedentary older Veterans. Everyone will be trained on use of the exergames, Nintendo Wii-Fit, that the investigators' team has found beneficial in improving balance and gait. They will be asked to exercise using Wii-Fit at home for 45 minutes daily five days/week for 12-weeks. Those that exercise less than recommended dose and those that exercise adequately but have low executive function will receive either real or sham magnetic stimulation to the front part of their brain over ten sessions paired with exercise training. All subjects will further complete 24-weeks of Wii-Fit home exercises. Adherence, executive function, balance and gait, self-efficacy, delay discounting, and falls will be measured periodically.

Key facts

Study ID

NCT03733041

Run by

VA Office of Research and Development

People needed

72

Starts

2019-04-01

Expected to finish

2025-05-31

Last updated by the study team

2026-02-02

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Sedentary Community Dwelling Veterans age 60 years and older
• Have Television (TV) at home
• Subjects reporting spending long periods of time in sedentary behavior by answering affirmatively to the question: 'For most days, do you feel you sit for too long (6-8 hours or more a day)?
• Some examples might include when watching TV, working at the computer / laptop or when doing sitting-based hobbies such as reading and sewing' will be included

You may not qualify if…

• GENERAL EXCLUSION CRITERIA
• Those that participate in regular physical activity for at least 30 minutes five or more days of the week
• EXCLUSIONARY DUE TO Wii-Fit Exercises
• Use of wheel chair for mobility
• Cognitive impairment [Montreal Cognitive Assessment (MoCA < 26)]
• Weight 325 lbs. (weight restriction of the Wii-Board)
• Absolute contraindications to exercise per The American College of Sports Medicine guidelines
• Those with medical conditions that in the opinion of the study physician are likely to compromise safe participation
• EXCLUSIONARY DUE TO rTMS
• Taking medications known to increase risk of seizures from 2012 Beers criteria such as bupropion, chlorpromazine, clozapine.
• Taking other medications known to increase risk of seizures such as tricyclic antidepressants.
• Taking ototoxic medications: Aminoglycosides, CisplatinHistory of seizures/ seizures in first degree relatives
• Those with implanted device
• History of stroke, aneurysm, or cranial neurosurgery
• History of bipolar disorder
• History of abnormal electroencephalogram (EEG)

Where it is running

• Central Arkansas Veterans Healthcare System , Little Rock, AR — Little Rock, Arkansas, United States

Full record on ClinicalTrials.gov

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