Comparison of 188-0551 Spray Versus Vehicle Spray in Subjects With Plaque Psoriasis (307)

Completed · Phase 3

Conditions studied: Plaque Psoriasis

In brief

This Phase 3 study (Study 307) has been designed to determine and compare the efficacy and safety of 188-0551 Spray and Vehicle Spray applied twice daily for up to four weeks in subjects with plaque psoriasis. Subjects will be instructed to apply the test article (188-0551 Spray or Vehicle Spray) to all psoriasis plaques within the designated Treatment Area twice daily for four weeks (Study Day 29), unless the investigator verifies the subject's psoriasis has cleared at Day 15, then test article application will be for 2 weeks (Study Day 15).

Key facts

Study ID

NCT03731052

Run by

Therapeutics, Inc.

People needed

217

Starts

2018-10-16

Expected to finish

2019-12-20

Last updated by the study team

2020-02-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subject is male or non-pregnant female and is at least 18 years of age at time of informed consent.
• Subject has provided written informed consent.
• Subject has a clinical diagnosis of stable plaque psoriasis involving a minimum of 2% and no more than 10% body surface area (BSA) (excluding the face, scalp, groin, axillae, and other intertriginous areas).
• Subject has moderate to severe plaque psoriasis.
• Subject is willing and able to apply the test article as directed, comply with study instructions, and commit to all follow-up visits for the duration of the study.
• Females must be post-menopausal , surgically sterile , or use an effective method of birth control. , Women of childbearing potential (WOCBP) must have a negative urine pregnancy test (UPT) at the Baseline Visit.

You may not qualify if…

• Subject has spontaneously improving or rapidly deteriorating plaque psoriasis.
• Subject has guttate, pustular, erythrodermic, or other non-plaque forms of psoriasis.
• Subject has palmar/plantar psoriasis.
• Subject is pregnant, lactating, or is planning to become pregnant during the study.
• Subject is currently enrolled in an investigational drug or device study.
• Subject has been previously enrolled in this study and treated with a test article.
• Other protocol defined inclusion or exclusion criteria assessed by the study staff may apply.

Where it is running

• Site 04 — Los Angeles, California, United States
• Site 14 — Ocala, Florida, United States
• Site 01 — Macon, Georgia, United States
• Site 11 — Rolling Meadows, Illinois, United States
• Site 13 — Rockville, Maryland, United States
• Site 10 — Clinton Township, Michigan, United States
• Site 12 — Fridley, Minnesota, United States
• Site 07 — Rochester, New York, United States
• Site 06 — High Point, North Carolina, United States
• Site 05 — Norman, Oklahoma, United States
• Site 03 — Philadelphia, Pennsylvania, United States
• Site 15 — Austin, Texas, United States
• Site 08 — San Antonio, Texas, United States
• Site 02 — Norfolk, Virginia, United States

Full record on ClinicalTrials.gov

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