The Effect of Almonds on Facial Aesthetics and Modulation of the Microbiome and Lipidome
Completed · Not applicable
Conditions studied: Wrinkle
In brief
The investigator hypothesizes that regular consumption of almonds will 1) improve the facial wrinkle severity in post-menopausal women, 2) improve the evenness of facial skin pigmentation, 3) diversify the gut microbiome and increase the short chain fatty acids in the blood, and 4) improve the skin barrier biophysical properties.
Key facts
- Study ID
- NCT03729700
- Run by
- University of California, Davis
- People needed
- 60
- Starts
- 2018-10-22
- Expected to finish
- 2021-06-22
- Last updated by the study team
- 2021-07-07
Who can join
Age: 18 and older, up to 100. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Postmenopausal women
- Fitzpatrick skin types 1 and 2
- Able to follow dietary intervention and attend all study visits
You may not qualify if…
- Those with a nut allergy
- Current smokers, those that have smoked within the past year, and former smokers with greater than a 20 pack-year history of smoking, as smoking is a independent risk factor and serves as a confounder for the development of facial wrinkles
- Those with an autoimmune photosensitive condition or a known genetic condition with a deficiency in collagen production (such as Ehler-Danlos), as this can be a confounder for the development of facial wrinkles
- Those that already obtain 20% of their energy intake from nut consumption
- Those with implausible reported energy intakes of <1,000 kcal/d or >3,000 kcal/d
- Individuals who are unwilling to discontinue vitamin E containing supplements and food sources during the washout and intervention
Where it is running
- UC Davis Department of Dermatology, Clinical Trials Unit — Sacramento, California, United States
Full record on ClinicalTrials.gov
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