A Study of Bempegaldesleukin (NKTR-214: BEMPEG) in Combination With Nivolumab Compared With the Investigator's Choice of a Tyrosine Kinase Inhibitor (TKI) Therapy (Either Sunitinib or Cabozantinib Monotherapy) for Advanced Metastatic Renal Cell Carcinoma (RCC)
Stopped early · Phase 3
Conditions studied: Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma
In brief
The main purpose of this study is to compare the objective response rate (ORR) and overall survival (OS) of bempegaldesleukin (NKTR-214: BEMPEG) combined with nivolumab to that of tyrosine kinase inhibitor (TKI) monotherapy (sunitinib or cabozantinib) in IMDC intermediate- or poor-risk patients and IMDC all-risk patients with previously untreated advanced renal cell carcinoma (RCC).
Key facts
- Study ID
- NCT03729245
- Run by
- Nektar Therapeutics
- People needed
- 623
- Starts
- 2018-12-18
- Expected to finish
- 2022-10-19
- Last updated by the study team
- 2023-04-11
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Western Regional Medical Center - CTCA - PPDS — Goodyear, Arizona, United States
- CARTI Cancer Center — Little Rock, Arkansas, United States
- City of Hope National Medical Center — Duarte, California, United States
- University of California Irvine — Orange, California, United States
- Innovative Clinical Research Institute — Whittier, California, United States
- University of Miami — Miami, Florida, United States
- Winship Cancer Institute, Emory University — Atlanta, Georgia, United States
- Tulane Medical Center — New Orleans, Louisiana, United States
- University of Maryland Greenebaum Cancer Center — Baltimore, Maryland, United States
- Comprehensive Cancer Centers of Nevada — Las Vegas, Nevada, United States
- North Shore Hematology Oncology Association PC — Port Jefferson Station, New York, United States
- Kettering Medical Center — Kettering, Ohio, United States
- Providence Cancer Institute, Franz Clinic — Portland, Oregon, United States
- Lehigh Valley Physician Group (LVPG) - Hematology Oncology — Allentown, Pennsylvania, United States
- Penn State Milton S Hershey Medical Center — Hershey, Pennsylvania, United States
- Thomas Jefferson University — Philadelphia, Pennsylvania, United States
- Eastern Regional Medical Center - CTCA — Philadelphia, Pennsylvania, United States
- MD Anderson Cancer Center — Houston, Texas, United States
- Huntsman Cancer Hospital - PPDS — Salt Lake City, Utah, United States
- Centro de Investigación Clínica - Clínica Viedma — Viedma, Río Negro Province, Argentina
- Centro de Investigación Pergamino S.A — Buenos Aires, Argentina
- Centro Médico Austral — Buenos Aires, Argentina
- Instituto Médico Especializado Alexander Fleming — Buenos Aires, Argentina
- Centro Médico Privado CEMAIC — Córdoba, Argentina
- Alaska Urological — Anchorage, Alaska, United States
Full record on ClinicalTrials.gov
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