Light Treatment Effectiveness (LITE) Study

Completed · Not applicable

Conditions studied: Psoriasis, Psoriatic Plaque

In brief

To compare the effectiveness, safety (tolerability), and duration of treatment response at 12 weeks of home versus office-based narrowband ultraviolet B phototherapy for the treatment of psoriasis

Key facts

Study ID

NCT03726489

Run by

University of Pennsylvania

People needed

783

Starts

2019-03-01

Expected to finish

2023-12-30

Last updated by the study team

2024-09-19

Who can join

Age: 12 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Willing and able to provide informed consent (age 18+) or parental permission and assent (ages 12-17)
• Age 12 or older
• Plaque or guttate psoriasis predominantly located on trunk and/or extremities, with a physician global assessment average of >1.0, and considered a candidate for phototherapy
• Patient is deemed willing and able to comply with either in-office or in-home phototherapy:
• In office: Able to travel about 3 times per week for 12 weeks from home, work and/or school during business hours of local site
• In home: Has space to accommodate home phototherapy unit and patient (or if 12-17, parent), willing and able to follow home phototherapy instructions
• New or established patient in the practice

You may not qualify if…

• Patients who are judged unable or unwilling to comply with either in office or in home phototherapy due to time, work, school, or other financial constraints
• Patients judged unable to follow home phototherapy protocol due to failure to demonstrate understanding of the following:
• How to operate the phototherapy device
• How to follow the dosing protocol
• Requirement to wear protective eyewear and genital protection equipment
• Patients with known history of lack of efficacy to phototherapy or treated with phototherapy 14 days prior to baseline visit
• Psoriasis predominantly located on scalp, body folds, genitals, palms and/or soles or with a physician global assessment average of ≤ 1.0
• Patients deemed unsafe to be treated with phototherapy:
• History of photosensitivity or autoimmune disease such as lupus or dermatomyositis which can be aggravated by ultraviolet radiation
• History of arsenic intake
• Unable to tolerate standing for required duration of treatment due to age or physical function
• History of melanoma or multiple non-melanoma skin cancers that in the opinion of the principal investigator contraindicates treatment with phototherapy
• Clinical site deems the participant is ineligible for reason other than eligibility or screening criteria.

Where it is running

• Total Skin & Beauty Dermatology Center — Birmingham, Alabama, United States
• Mayo Clinic Arizona — Scottsdale, Arizona, United States
• Johnson Dermatology — Fort Smith, Arkansas, United States
• University of Southern California — Los Angeles, California, United States
• University of California, San Francisco — San Francisco, California, United States
• George Washington University — Washington D.C., District of Columbia, United States
• Howard University — Washington D.C., District of Columbia, United States
• Northwestern University — Chicago, Illinois, United States
• Dawes Fretzin Clinical Research — Indianapolis, Indiana, United States
• MD Claiborne and Associates, LLC — New Orleans, Louisiana, United States
• MaineHealth/Maine Medical Center — Portland, Maine, United States
• Johns Hopkins University — Baltimore, Maryland, United States
• DermAssociates LLC — Silver Spring, Maryland, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• Dermatology Specialist of Brighton — Brighton, Michigan, United States
• Henry Ford Health System — Detroit, Michigan, United States
• Washington University in St. Louis — St Louis, Missouri, United States
• Psoriasis Treatment Center of Central New Jersey — East Windsor, New Jersey, United States
• Heymann, Manders, Green, and Sommer, LLC — Marlton, New Jersey, United States
• University of New Mexico — Albuquerque, New Mexico, United States
• HHC Kings County Hospital — Brooklyn, New York, United States
• SUNY Downstate Health Sciences University — Brooklyn, New York, United States
• Buffalo Medical Group — Buffalo, New York, United States
• Infinity Dermatology NYC — Queens, New York, United States
• Montefiore Medical Center — The Bronx, New York, United States

Full record on ClinicalTrials.gov

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