A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM

Completed · Phase 2/Phase 3

Conditions studied: Hypertrophic Cardiomyopathy, Obstructive Hypertrophic Cardiomyopathy, Non-obstructive Hypertrophic Cardiomyopathy

In brief

Approximately 30 sites that enrolled participants in the MAVERICK-HCM (MYK-461-006) study in the United States (US) will initiate this study. Approximately 90 sites that enrolled participants in the EXPLORER-HCM (MYK-461-005) study in the US, Europe, and Israel will initiate this study. Note: Approximately 30 centers overlap between MAVERICK and EXPLORER.

Key facts

Study ID

NCT03723655

Run by

Bristol-Myers Squibb

People needed

314

Starts

2018-09-27

Expected to finish

2026-01-16

Last updated by the study team

2026-02-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Local Institution - 0058 — Los Angeles, California, United States
• Local Institution - 0066 — San Francisco, California, United States
• Local Institution - 0063 — Stanford, California, United States
• Local Institution - 0043 — New Haven, Connecticut, United States
• Local Institution - 0067 — Jacksonville, Florida, United States
• Local Institution - 0050 — Chicago, Illinois, United States
• Local Institution - 0070 — Indianapolis, Indiana, United States
• Local Institution - 0049 — Iowa City, Iowa, United States
• Local Institution - 0054 — Boston, Massachusetts, United States
• Local Institution - 0051 — Ann Arbor, Michigan, United States
• Local Institution - 0074 — Grand Rapids, Michigan, United States
• Local Institution - 0048 — St Louis, Missouri, United States
• Local Institution - 0060 — New York, New York, United States
• Local Institution - 0056 — New York, New York, United States
• Local Institution - 0071 — Charlotte, North Carolina, United States
• Local Institution - 0047 — Durham, North Carolina, United States
• Local Institution - 0052 — Cincinnati, Ohio, United States
• Local Institution - 0044 — Portland, Oregon, United States
• Local Institution - 0068 — Bethlehem, Pennsylvania, United States
• Local Institution - 0046 — Philadelphia, Pennsylvania, United States
• Local Institution - 0064 — Pittsburgh, Pennsylvania, United States
• Local Institution - 0073 — Memphis, Tennessee, United States
• Local Institution - 0061 — Dallas, Texas, United States
• Local Institution - 0055 — Houston, Texas, United States
• Local Institution - 0045 — Scottsdale, Arizona, United States

Full record on ClinicalTrials.gov

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