Antibiotic Resistance in Global Pediatric Oncology Centers
Completed
Conditions studied: Antibiotic Resistant Infection
In brief
Antibiotic resistance is one of the major health threats facing global as well as domestic populations, however it is not well characterized in pediatric patients. Pediatric patients receiving cancer-directed therapy have several risk factors implicated in development of antibiotic resistance including multiple courses of antibiotics, repeated exposures to the hospital environment, indwelling devices and chemotherapy-related damage to mucosal barriers. The investigators propose to capitalize upon the unique position of St. Jude Global within the global pediatric oncology community by using its regional alliance network to describe the molecular epidemiology of antibiotic resistance in Gram-negative bacteria in this population. Primary Objectives 1. Describe the epidemiology and the phenotypic and previously determined molecular determinants of antimicrobial resistance in Gram-negative organisms isolated from pediatric diagnostic specimens in selected Central American and US sites with capacity to treat pediatric cancer 2. Utilize strain typing by whole genome sequencing to describe relatedness between organisms at participating sites
Key facts
- Study ID
- NCT03721562
- Run by
- St. Jude Children's Research Hospital
- People needed
- 560
- Starts
- 2019-02-26
- Expected to finish
- 2022-07-29
- Last updated by the study team
- 2022-08-03
Who can join
Age: any, up to 18. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Pediatric (0-18 years of age) patients having a bacteria isolated from a sterile site (blood, cerebrospinal fluid, body fluid) or urine positive for a Gram-negative bacteria nonsusceptible to at least 1 of the following: third generation cephalosporin, fourth generation cephalosporin or carbapenem OR screening positive for carbapenemase or extended spectrum beta lactamase (ESBL) production.
You may not qualify if…
- Repeated isolation of the same organism from the same patient within the study period.
Where it is running
- St. Jude Children's Research Hospital — Memphis, Tennessee, United States
- Texas Children's Hospital — Houston, Texas, United States
- Hospital Nacional de Niños Benjamín Bloom — San Salvador, El Salvador
- Unidad Nacional de Oncología Pediátrica — Guatemala City, Guatemala
- Hospital del Niño — Panama City, Panama
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.