Inflammatory Mediators of Acute Kidney Injury in Intensive Care

Recruiting now

Conditions studied: Sepsis, Surgery, Acute Kidney Injury

In brief

Acute kidney injury (AKI) affects more than 50% of patients admitted to the intensive care unit. The most common underlying cause is sepsis. Severe AKI in combination with sepsis is associated with high mortality. The mechanisms for sepsis-induced AKI are largely unknown. Our hypothesis is that the inflammatory response to an infection cause collateral damage to host tissue and contributes to the development of AKI. In this study we want to investigate the presence of novel inflammatory mediators in patients with sepsis, patients subjected to major surgery (sterile inflammation) and non-inflamed patients and correlate their levels with the risk for AKI.

Key facts

Study ID

NCT03720860

Run by

Uppsala University

People needed

100

Starts

2018-01-01

Expected to finish

2026-05-01

Last updated by the study team

2026-01-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients admitted to the intensive/post operative care unit
• with septic shock or
• post major surgery or
• after intoxication with a chemical compund

You may not qualify if…

• Pregnancy or
• Breast feeding or
• Chronic kidney disease or
• intoxication with nephrotoxic compund or
• lack of informed consent

Where it is running

• Akademiska sjukhuset, Centraloperation — Uppsala, Uppsala County, Sweden (enrolling)

Full record on ClinicalTrials.gov

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