Muscle Dysfunction in Critical Illness

Completed

Conditions studied: Critical Illness, Intensive Care (ICU) Myopathy, PICS, Muscle Weakness

In brief

Patients surviving critical illness suffered significant skeletal muscle dysfunction and weakness that impacts their functionality and independence. The primary purpose of this project is to develop a classification system based on the health and function of the muscle at very early time points during critical illness. The investigators will determine if muscle ultrasound can predict functional recovery at six-months post hospital discharge. Researchers will assess muscle health and function from starting day one of admission to ICU and continue until six months of recovery. In addition to muscle ultrasound, the investigators will assess muscle strength and power, and perform muscle tissue analysis on a subset of individuals. These findings will be correlated to physical function and independence at six-month follow-up.

Key facts

Study ID

NCT03717831

Run by

University of Kentucky

People needed

66

Starts

2018-10-17

Expected to finish

2019-07-15

Last updated by the study team

2020-01-31

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• admitted to medicine, cardio-thoracic or trauma ICU
• initial primary or secondary diagnosis of acute respiratory distress/failure
• mechanical ventilation (predicted for at-least 72 hours)

You may not qualify if…

• receiving palliative treatment
• attending physician excluding due to high-risk of mortality
• neurological injury or event
• lower extremity amputee
• pregnant
• non-ambulatory prior to admission

Where it is running

• University of Kentucky — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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