The Effect of 10-Week Exercise Training on Children With Asthma
Withdrawn before enrolling · Not applicable
Conditions studied: Asthma in Children
In brief
The goal of this research is to determine whether 10-weeks of exercise training can benefit asthmatic children and young adults with a history of exercise-induced bronchoconstriction (EIB). The investigators will also study an exciting newly discovered aspect of gene expression regulation in the white blood cells known as epigenetics: a process that takes place when genomic changes happen as a result of exposure to the environment. This study is based on emerging exciting new data from this and other laboratories demonstrating that (a) white blood cells play an important role in bronchoconstriction in children, (b) gene and cytokine expression in circulating white blood cells are abnormal in asthma and (c) brief exercise may change genomic and inflammatory- profiles of these cells.Physical activity is an essential component of growth and health in children, thus, this research will lead to improved clinical uses of exercise as preventive and adjunctive therapy in the current epidemic of childhood asthma
Key facts
- Study ID
- NCT03716219
- Run by
- University of California, Irvine
- People needed
- 0
- Starts
- 2013-10-10
- Expected to finish
- 2013-10-10
- Last updated by the study team
- 2021-02-12
Who can join
Age: 8 and older, up to 35. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Good health
- Physical activity
- No evidence of disease or disability
- Diagnosed with persistent asthma (asthma subjects)
- BMI<95 percentile
You may not qualify if…
- Use of illegal drugs or alcohol
- Very high physical fitness
- Pregnancy
- More than two asthma attack per week (asthma subjects)
Where it is running
- Pediatric Exercise and Genomics Research Center, University of California, Irvine — Irvine, California, United States
Full record on ClinicalTrials.gov
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