Measurement of the Partial Pressure of Oxygen in Cutaneous Tumors Using Electron Paramagnetic Resonance (EPR) Oximetry
Stopped early · Not applicable
Conditions studied: Skin Lesion, Skin Cancer, Skin Melanoma, Tumor Skin
In brief
This protocol will take measurements of a variety of tumors involving the skin in order to assess changes in tumor oxygen from hyperoxygenation therapy and standard cancer-directed treatments, to demonstrate the clinical feasibility of using in vivo Electron Paramagnetic Resonance (EPR) Oximetry to obtain clinically useful measurements of tumor oxygen levels from cancer patients.
Key facts
- Study ID
- NCT03716193
- Run by
- West Virginia University
- People needed
- 3
- Starts
- 2019-10-17
- Expected to finish
- 2022-03-31
- Last updated by the study team
- 2026-02-27
Who can join
Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Pathology-proven (histology or cytology) malignancy of any histology and site of origin
- Visible tumor (primary or metastasis) involving the skin of at least 6 mm in diameter
- Negative serum or urine pregnancy test within 72 hours prior to registration for women of childbearing potential
You may not qualify if…
- Implanted electric, magnetic or mechanically activated devices like a pacemaker, defibrillator, nerve stimulator, cochlear implant or portable infusion pump. Also individuals who have any non-MRI compatible implants
- Individuals who have a ferromagnetic foreign body located in their body
- Prior adverse reaction to a charcoal product (e.g., a local hypersensitive response from a black tattoo or from ingestion of activated charcoal)
- Prior adverse reaction to gum Arabic, which is an ingredient in the India ink
- Prior allergic reaction to medical adhesives
- Psychiatric illness/social situations that would limit compliance with study requirements
- Pregnant or lactating women. There is no known harm to the woman or her fetus from participating; this is precautionary only
Where it is running
- Todd Tenenholz — Morgantown, West Virginia, United States
Full record on ClinicalTrials.gov
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