Safety and Efficacy of Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) Versus Lenvatinib as First-line Therapy in Participants With Advanced Hepatocellular Carcinoma (MK-7902-002/E7080-G000-311/LEAP-002)

Completed · Phase 3 · Has a placebo group

Conditions studied: Carcinoma, Hepatocellular

In brief

The purpose of this study is to evaluate the safety and efficacy of lenvatinib (E7080/MK-7902) in combination with pembrolizumab (MK-3745) versus lenvatinib in combination with placebo as first-line therapy for the treatment of advanced hepatocellular carcinoma in adult participants. The primary hypotheses of this study are that lenvatinib plus pembrolizumab is superior to lenvatinib plus placebo with respect to progression-free survival (PFS) and overall survival (OS).

Key facts

Study ID

NCT03713593

Run by

Merck Sharp & Dohme LLC

People needed

794

Starts

2018-12-31

Expected to finish

2024-09-24

Last updated by the study team

2026-02-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Is male or female and ≥18 years of age at the time of signing the informed consent
• Has a diagnosis of hepatocellular carcinoma confirmed by radiology, histology, or cytology
• Has Barcelona Clinic Liver Cancer (BCLC) Stage C disease, or BCLC Stage B disease not amenable to locoregional therapy or refractory to locoregional therapy, and not amenable to a curative treatment approach
• Has a Child-Pugh class A liver score
• Has a predicted life expectancy of >3 months
• Has at least one measurable hepatocellular carcinoma (HCC) lesion based on RECIST 1.1 as confirmed by BICR
• Has an Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0 to 1
• Participants with hepatitis B will be eligible as long as their virus is well controlled

You may not qualify if…

• Has had esophageal or gastric variceal bleeding within the last 6 months
• Has gastrointestinal malabsorption, gastrointestinal anastomosis, or any other condition that might affect the absorption of lenvatinib
• Has a preexisting Grade ≥3 gastrointestinal or non-gastrointestinal fistula
• Has clinically significant hemoptysis from any source or tumor bleeding within 2 weeks prior to the first dose of study intervention
• Has significant cardiovascular impairment within 12 months of the first dose of study intervention such as history of congestive heart failure greater than New York Heart Association (NYHA) Class II, unstable angina, myocardial infarction or cerebrovascular accident stroke, or cardiac arrhythmia associated with hemodynamic instability
• Has had major surgery to the liver within 4 weeks prior to the first dose of study intervention
• Has had a minor surgery (ie, simple excision) within 7 days prior to the first dose of study intervention
• Has serious non-healing wound, ulcer, or bone fracture
• Has received any systemic chemotherapy for HCC or chemotherapy for any malignancy in the past 3 years
• Has received prior therapy with an anti-programmed cell death 1 (ant-PD-1), anti-programmed cell death ligand 1 (anti-PD-L1), or anti- programmed cell death ligand 2 (anti-PD-L2) agent or with an agent directed to another stimulatory or co-inhibitory T-cell receptor (eg, cytotoxic T-lymphocyte-associated protein 4 [CTLA-4], OX-40, or CD137)
• Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior the first dose of study intervention
• Has a known additional malignancy that is progressing or has required active treatment within the past 3 years with the exceptions of basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or carcinoma in situ (eg, breast carcinoma, cervical cancer in situ) that has undergone potentially curative therapy
• Has a known history of, or any evidence of, central nervous system (CNS) metastases and/or carcinomatous meningitis as assessed by local site investigator
• Has severe hypersensitivity (≥Grade 3) to study intervention and/or any of their excipients
• Has an active autoimmune disease that has required systemic treatment in past 2 years
• Has a history of (non-infectious) pneumonitis that required steroids or has current pneumonitis
• Has urine protein ≥1 grams/24 hours
• Prolongation of corrected QT (QTc) interval to >480 milliseconds (corrected by Fridericia Formula)
• Has left ventricular ejection fraction (LVEF) below the institutional normal range as determined by multigated acquisition scan (MUGA) or echocardiogram (ECHO)
• Has an active infection requiring systemic therapy with the exceptions of hepatitis B virus (HBV) or hepatitis C virus (HCV)
• Has a known history of human immunodeficiency virus (HIV) infection
• Has known active tuberculosis (Bacillus tuberculosis)
• Has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the study, interfere with the participant's participation for the full duration of the study, or is not in the best interest of the participant to participate, in the opinion of the treating investigator
• Has a known psychiatric or substance abuse disorder that would interfere with the participant's ability to cooperate with the requirements of the study
• Is pregnant or breastfeeding or expecting to conceive or father children within the projected duration of the study, starting with the screening visit through 120 days after the last dose of study intervention

Where it is running

• City of Hope Comprehensive Cancer Center ( Site 0587) — Duarte, California, United States
• Scripps Health ( Site 0644) — La Jolla, California, United States
• Pacific Hematology Oncology Associates ( Site 0588) — San Francisco, California, United States
• UCLA ( Site 0589) — Santa Monica, California, United States
• Georgetown University ( Site 0594) — Washington D.C., District of Columbia, United States
• University of Miami, Sylvester Comprehensive Cancer Center ( Site 0596) — Miami, Florida, United States
• Advent Health ( Site 0595) — Orlando, Florida, United States
• Tampa General Medical Group ( Site 0629) — Tampa, Florida, United States
• Emory University Winship Cancer Institute ( Site 0639) — Atlanta, Georgia, United States
• University of Kansas Cancer Center ( Site 0600) — Westwood, Kansas, United States
• Massachusetts General Hospital ( Site 0603) — Boston, Massachusetts, United States
• Beth Israel Deaconess Medical Center ( Site 0716) — Boston, Massachusetts, United States
• Icahn School of Medicine at Mount Sinai ( Site 0611) — New York, New York, United States
• University of Rochester ( Site 0613) — Rochester, New York, United States
• Stony Brook University Medical Center - Cancer Center ( Site 0612) — Stony Brook, New York, United States
• University of Oklahoma Health Science Center ( Site 0625) — Oklahoma City, Oklahoma, United States
• Oregon Health & Science University ( Site 0645) — Portland, Oregon, United States
• Eastern Regional Medical Center, Inc. ( Site 0626) — Philadelphia, Pennsylvania, United States
• Central Texas Veterans Healthcare System ( Site 0617) — Temple, Texas, United States
• Cancer Care Northwest ( Site 0636) — Spokane, Washington, United States
• Royal Prince Alfred Hospital ( Site 0001) — Camperdown, New South Wales, Australia
• Princess Alexandra Hospital ( Site 0007) — Wooloongabba, Queensland, Australia
• Monash Health-Monash Medical Centre ( Site 0004) — Clayton, Victoria, Australia
• St Vincents Hospital Melbourne ( Site 0003) — Fitzroy, Victoria, Australia
• The University of Arizona Cancer Center - North Campus ( Site 0621) — Tucson, Arizona, United States

Full record on ClinicalTrials.gov

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