Can Intraosseous Antibiotics Improve the Results of Irrigation & Debridement and Prosthetic Retention for PJI?
Enrolling by invitation · Phase 4
Conditions studied: Joint Infection
In brief
Purpose of Study: In order to improve upon the variable results seen in irrigation and debridement for periprosthetic infection, we ask if the use of intraosseous regional administration of antibiotics at the time of irrigation and debridement will improve the modest success of standard irrigation and debridement. We will use the existing literature on standard irrigation and debridement procedures to compare with the results of the irrigation and debridement with the use of intraosseous antibiotics. Impact Question: How will this study benefit the patient? Currently when an I\&D fails, the patient needs to undergo two more major procedures: 1) implant removal and 2) reimplantation of the prosthesis. Any improvement in the results of a standard irrigation and debridement procedure may decrease the number of patients having to go through further extensive procedures to cure their infection.
Key facts
- Study ID
- NCT03713528
- Run by
- OrthoCarolina Research Institute, Inc.
- People needed
- 100
- Starts
- 2020-01-14
- Expected to finish
- 2027-06-01
- Last updated by the study team
- 2026-04-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
Where it is running
- University of California, San Francisco — San Francisco, California, United States
- University of Florida — Gainesville, Florida, United States
- Cleveland Clinic Florida — Weston, Florida, United States
- Rush University — Chicago, Illinois, United States
- University of Nebraska — Omaha, Nebraska, United States
- New York University - Langone — New York, New York, United States
- Atrium Mercy Hospital — Charlotte, North Carolina, United States
- OrthoCarolina Research Institute/OrthoCarolina — Charlotte, North Carolina, United States
- Novant Health Charlotte Orthopedic Hospital — Charlotte, North Carolina, United States
- University of Utah — Salt Lake City, Utah, United States
Full record on ClinicalTrials.gov
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