HCT+F vs. HCT Alone in Critically Ill Medical Septic Shock Patients
Completed · Phase 2
Conditions studied: Septic Shock
In brief
This study will be conducted as a single-center, prospective, open-label, randomized trial that will evaluate adult patients admitted with septic shock to the medical critical care unit (MCC). The objective of the study is to determine if the use of hydrocortisone plus fludrocortisone is associated with a faster resolution of shock (defined as 24 hours vasopressor free) when compared to the use of hydrocortisone alone in medical, critically ill septic shock patients.
Key facts
- Study ID
- NCT03710187
- Run by
- University of Tennessee Medical Center
- People needed
- 84
- Starts
- 2018-11-05
- Expected to finish
- 2019-09-27
- Last updated by the study team
- 2021-05-20
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Critically ill medical patients requiring addition of stress dose steroid therapy (hydrocortisone) in addition to pressors for septic shock management during ICU stay
- Fludrocortisone administered within 24 hours after initiation of hydrocortisone if in combination therapy group
You may not qualify if…
- Use of fludrocortisone and/or hydrocortisone for any reason other than septic shock management during ICU stay
- Fludrocortisone/hydrocortisone initiated by any service other than critical care medicine
- Prior use of fludrocortisone/hydrocortisone at time of admission (home or outside facility)
- Patients not appropriate for study inclusion as determined by provider discretion
- Patients receiving steroid therapy not in accordance with assigned group per location (MCC1 or MCC2)
- Patients re-admitted to the MCC during the same admission and restarted on vasopressor therapy will be noted during data collection and only the initial admission will be included for analysis
- Any patient receiving greater than one dose of hydrocortisone 100 mg
- Physical or medical contraindication to receiving PO or PER FT (per feeding tube) fludrocortisone
Where it is running
- University of Tennessee Medical Center — Knoxville, Tennessee, United States
Full record on ClinicalTrials.gov
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