Open-label Study to Assess Increasing Levels of NAD+(Nicotinamide Adenine Dinucleotide)

Completed · Not applicable

Conditions studied: Increase in Blood Levels of Nicotinamide Adenine Dinucleotide (NAD+)

In brief

The purpose of this study is to assess an effective single oral supplement or combination of oral supplements for increasing whole blood NAD+ levels.

Key facts

Study ID

NCT03707652

Run by

Supplement Formulators, Inc.

People needed

8

Starts

2018-03-12

Expected to finish

2018-05-24

Last updated by the study team

2018-10-18

Who can join

Age: 30 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Able to provide written Informed Consent
• Able to follow verbal and written study directions in English
• Adult men and women between age 30-80 years (inclusive)
• Women of reproductive potential will practice contraception during the Investigation
• Body Mass Index (BMI) between 18.5 and 35 kg/m2
• Must not be taking or be willing to stop taking any supplements containing any form of niacin for seven days prior to baseline and for the duration of the study.
• Must not be using or be willing to stop use of any "100%" or higher niacin fortified foods from seven days prior to screening visit and for the duration of the investigation
• Able to maintain consistent diet and lifestyle habits throughout the study
• Volunteers with chronic but stable and well controlled medical conditions (i.e., hypertension controlled by a consistent dose of medication for a minimum of six months; chronic use of consistent dose of blood-thinning medication; diet-controlled Type II diabetes) may participate at the discretion of the PI or Sub-I.
• Willing and able to provide fasting blood samples
• Able to attend scheduled visits at the Life Extension Clinical Research (LECR) facility

You may not qualify if…

• Current use of prescription or over-the-counter nicotinic acid
• Use of statin drugs
• Having used any tobacco product or used a recreational drug in the past 6 months
• Medically complicated [i.e., diabetes requiring insulin; uncontrolled hypertension (blood pressure readings at screening/baseline > 140 systolic or > 90 diastolic on two consecutive readings); etc.] at the discretion of the PI or Sub-I
• Having abnormal screening laboratory test values or other lab test result(s) that would preclude study participation in the judgment of the PI or Sub-I
• Woman who is pregnant, nursing, or planning a pregnancy. Non-pregnant status of women of childbearing potential will be confirmed during each Day 3 Cycle LECR visit (Wednesday or Thursday) via serum pregnancy test.
• Currently, or within the past 30 days, enrolled in a different clinical investigation
• Inability to provide a venous blood sample
• Unable to refrain from any alcohol consumption for the duration of the study
• Unable or unwilling to provide written informed consent for participation in study

Where it is running

• Life Extension Clinical Research, Inc. — Fort Lauderdale, Florida, United States

Full record on ClinicalTrials.gov

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