Collateral Circulation to LAD and Wellens Sign

Status unconfirmed

Conditions studied: Coronary Artery Disease, Acute Myocardial Infarction, Acute Myocardial Infarction of Anterior Wall, Collateral Circulation, Any Site

In brief

Overall Aim Coronary artery disease significantly contributes to morbidity and mortality in the United States. Atherosclerotic disease can lead to stenosis of the coronary arteries and subsequent cardiac hypoperfusion. Patients with a critical stenosis of the LAD, potentially leading to acute anterior wall myocardial infarction, may be asymptomatic at presentation with subtle EKG changes as its only manifestation. It is imperative for physicians to recognize patients with new T wave inversions in leads V2-V3 as the standard course of management may lead to poor prognosis. The purpose of this study is to determine if collateral circulation to the left anterior descending (LAD) artery will mask the presence of a Wellens sign and therefore diminish its diagnostic utility. The conclusion of this study would raise awareness for physicians in light of an absent Wellens sign. Hypothesis The presence of coronary collateral circulation to the LAD masks the presence of a Wellens sign (both Type 1 and Type 2) in precordial leads V2-V4.

Key facts

Study ID
NCT03707626
Run by
Coney Island Hospital, Brooklyn, NY
People needed
1500
Starts
2018-09-26
Expected to finish
2019-06-23
Last updated by the study team
2018-10-16

Who can join

Age: 18 and older, up to 89. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

You may not qualify if…

Where it is running

Full record on ClinicalTrials.gov

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