Degradation of the Glycocalyx in Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage

Status unconfirmed · Not applicable

Conditions studied: Aneurysmal Subarachnoid Hemorrhage

In brief

This study will provide novel information to the literature base for the pathophysiology of aneurysmal subarachnoid hemorrhage. The association of breakdown products in the serum of aSAH patients were reported in a very small case series of 3 patients, as mentioned above. However, while their results are intriguing and encouraging, our study will provide more definitive information about the GC in aSAH. If there is a positive correlation, the results of this study will guide future investigations into new therapies for this devastating disease such as MMP inhibition with doxycycline.

Key facts

Study ID

NCT03706768

Run by

University of Virginia

People needed

42

Starts

2018-05-01

Expected to finish

2020-05-01

Last updated by the study team

2019-04-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• • Age 18 years of age and older
• Cerebral aneurysm on CT-angio

You may not qualify if…

• • comfort care only orders,
• the absence of an aneurysm on CT-angiography,
• onset of aneurysm rupture > 24 hours,
• and inability to obtain informed consent from patient or family pregnant women

Where it is running

• University of Virginia Health System — Charlottesville, Virginia, United States (enrolling)

Full record on ClinicalTrials.gov

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