Identification of the Pre-exposure Prophylaxis (PrEP) Cascade for Women.

Completed

Conditions studied: Pre-Exposure Prophylaxis

In brief

Pre-exposure prophylaxis (PrEP) is a daily pill that greatly reduces the risk of transmission of human immunodeficiency virus (HIV), however the barriers to PrEP use for women are understudied and PrEP is underutilized by women. Partnering with the DC Department of Health and the DC Center for AIDS Research (DC-CFAR), the overarching goals are (1) to identify and populate the PrEP cascade for women, (2) to provide a blueprint for family planning providers to integrate HIV prevention into their practices and target evidence-based interventions to the women at highest risk for HIV in their communities, and (3) to evaluate the cost-effectiveness of this intervention. The overarching hypotheses are that (1) the timeline and roadmap to PrEP adoption and the PrEP cascade will be different for cis-gender women than that described for men who have sex with men (MSM) and transgender women, (2) women seeking family planning services will be eligible for and interested in PrEP and family planning providers are ideally situated to provide this care, and (3) provision of PrEP in the family planning setting will be cost-effective. This research proposes to evaluate (1) PrEP cascade of events for women (eligibility for PrEP, acceptability/interest in PrEP, access/linkage to a PrEP program, initiation of PrEP, retention, and adherence to PrEP) and (2) the integration of universal screening for PrEP and PrEP provision into a women's family planning clinic. This research will allow for targeted evidence-based interventions to reach women at high-risk for HIV and will provide a blueprint for the implementation of PrEP services in the family planning setting nationally.

Key facts

Study ID

NCT03705663

Run by

Medstar Health Research Institute

People needed

25

Starts

2018-07-01

Expected to finish

2020-04-27

Last updated by the study team

2022-12-15

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Cis-gender women
• Interested in PrEP and/or initiating PrEP

You may not qualify if…

• HIV positive
• Severe liver disease
• Severe renal (kidney) disease
• Signs/symptoms of acute HIV infection (such as fever, swollen lymph nodes, sore throat, skin rash, body aches)
• Do not speak English or Spanish
• No access to a telephone for follow-up
• Planning to leave the Washington, DC area in the next 6 months

Where it is running

• DC Health and Wellness Center — Washington D.C., District of Columbia, United States
• Rachel Scott — Washington D.C., District of Columbia, United States

Full record on ClinicalTrials.gov

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